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A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus

Author

Listed:
  • Michael H. Berry

    (Oregon Health & Science University
    Oregon Health & Science University)

  • Michael Moldavan

    (Oregon Health and Science University
    Oregon Health & Science University)

  • Tavita Garrett

    (Oregon Health & Science University
    Oregon Health & Science University)

  • Marc Meadows

    (Oregon Health & Science University
    Oregon Health & Science University)

  • Olga Cravetchi

    (Oregon Health and Science University
    Oregon Health & Science University)

  • Elizabeth White

    (Oregon Health & Science University)

  • Joseph Leffler

    (Oregon Health & Science University)

  • Henrique Gersdorff

    (Oregon Health & Science University
    Oregon Health & Science University
    Oregon Health & Science University)

  • Kevin M. Wright

    (Oregon Health & Science University)

  • Charles N. Allen

    (Oregon Health and Science University
    Oregon Health & Science University)

  • Benjamin Sivyer

    (Oregon Health & Science University
    Oregon Health & Science University)

Abstract

Visual input to the hypothalamus from intrinsically photosensitive retinal ganglion cells (ipRGCs) influences several functions including circadian entrainment, body temperature, and sleep. ipRGCs also project to nuclei such as the supraoptic nucleus (SON), which is involved in systemic fluid homeostasis, maternal behavior, social behaviors, and appetite. However, little is known about the SON-projecting ipRGCs or their relationship to well-characterized ipRGC subtypes. Using a GlyT2Cre mouse line, we show a subtype of ipRGCs restricted to the dorsal retina that selectively projects to the SON. These ipRGCs tile a dorsal region of the retina, forming a substrate for encoding ground luminance. Optogenetic activation of their axons demonstrates they release the neurotransmitter glutamate in multiple regions, including the suprachiasmatic nucleus (SCN) and SON. Our results challenge the idea that ipRGC dendrites overlap to optimize photon capture and suggests non-image forming vision operates to sample local regions of the visual field to influence diverse behaviors.

Suggested Citation

  • Michael H. Berry & Michael Moldavan & Tavita Garrett & Marc Meadows & Olga Cravetchi & Elizabeth White & Joseph Leffler & Henrique Gersdorff & Kevin M. Wright & Charles N. Allen & Benjamin Sivyer, 2023. "A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36955-6
    DOI: 10.1038/s41467-023-36955-6
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    References listed on IDEAS

    as
    1. Lindsey D. Salay & Nao Ishiko & Andrew D. Huberman, 2018. "A midline thalamic circuit determines reactions to visual threat," Nature, Nature, vol. 557(7704), pages 183-189, May.
    2. Yifan Yao & Alana B’nai Taub & Joseph LeSauter & Rae Silver, 2021. "Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. S. Hattar & R. J. Lucas & N. Mrosovsky & S. Thompson & R. H. Douglas & M. W. Hankins & J. Lem & M. Biel & F. Hofmann & R. G. Foster & K.-W. Yau, 2003. "Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice," Nature, Nature, vol. 424(6944), pages 75-81, July.
    4. S.-K. Chen & T. C. Badea & S. Hattar, 2011. "Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs," Nature, Nature, vol. 476(7358), pages 92-95, August.
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    1. Elyashiv Zangen & Shira Hadar & Christopher Lawrence & Mustafa Obeid & Hala Rasras & Ella Hanzin & Ori Aslan & Eyal Zur & Nadav Schulcz & Daniel Cohen-Hatab & Yona Samama & Sarah Nir & Yi Li & Irina D, 2024. "Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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