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Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain

Author

Listed:
  • Yifan Yao

    (Columbia University Department of Psychology)

  • Alana B’nai Taub

    (Columbia University Department of Psychology)

  • Joseph LeSauter

    (Barnard College)

  • Rae Silver

    (Columbia University Department of Psychology
    Barnard College
    Graduate School, Columbia University Medical School)

Abstract

There is only one known portal system in the mammalian brain - that of the pituitary gland, first identified in 1933 by Popa and Fielding. Here we describe a second portal pathway in the mouse linking the capillary vessels of the brain’s clock suprachiasmatic nucleus (SCN) to those of the organum vasculosum of the lamina terminalis (OVLT), a circumventricular organ. The localized blood vessels of portal pathways enable small amounts of important secretions to reach their specialized targets in high concentrations without dilution in the general circulatory system. These brain clock portal vessels point to an entirely new route and targets for secreted SCN signals, and potentially restructures our understanding of brain communication pathways.

Suggested Citation

  • Yifan Yao & Alana B’nai Taub & Joseph LeSauter & Rae Silver, 2021. "Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25793-z
    DOI: 10.1038/s41467-021-25793-z
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    Cited by:

    1. Michael H. Berry & Michael Moldavan & Tavita Garrett & Marc Meadows & Olga Cravetchi & Elizabeth White & Joseph Leffler & Henrique Gersdorff & Kevin M. Wright & Charles N. Allen & Benjamin Sivyer, 2023. "A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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