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Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs

Author

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  • S.-K. Chen

    (Johns Hopkins University)

  • T. C. Badea

    (Retinal Circuit Development & Genetics Unit, N-NRL/NEI/NIH)

  • S. Hattar

    (Johns Hopkins University
    Johns Hopkins University-School of Medicine)

Abstract

Variation in the third retinal photoreceptor For many years, it was thought that rods and cones were the only light-detecting cells in the mammalian retina, but about 20 years ago a third photoreceptor was identified, the intrinsically photosensitive retinal ganglion cells (ipRGCs). Expressing the photo-pigment melanopsin, these cells assist in the regulation of circadian photoentrainment and help to drive the pupillary light reflex. Chen et al. now show that these two functions are associated with distinct subpopulations of ipRGCs, defined by specific molecular factors and acting in parallel.

Suggested Citation

  • S.-K. Chen & T. C. Badea & S. Hattar, 2011. "Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs," Nature, Nature, vol. 476(7358), pages 92-95, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7358:d:10.1038_nature10206
    DOI: 10.1038/nature10206
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    Cited by:

    1. Michael H. Berry & Michael Moldavan & Tavita Garrett & Marc Meadows & Olga Cravetchi & Elizabeth White & Joseph Leffler & Henrique Gersdorff & Kevin M. Wright & Charles N. Allen & Benjamin Sivyer, 2023. "A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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