A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
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DOI: 10.1038/s41467-023-36629-3
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- Chris B. Moore & Daniel T. Bergstralh & Joseph A. Duncan & Yu Lei & Thomas E. Morrison & Albert G. Zimmermann & Mary A. Accavitti-Loper & Victoria J. Madden & Lijun Sun & Zhengmao Ye & John D. Lich & , 2008. "NLRX1 is a regulator of mitochondrial antiviral immunity," Nature, Nature, vol. 451(7178), pages 573-577, January.
- Jonathan R. Friedman & Jodi Nunnari, 2014. "Mitochondrial form and function," Nature, Nature, vol. 505(7483), pages 335-343, January.
- Simone M. Haag & Muhammet F. Gulen & Luc Reymond & Antoine Gibelin & Laurence Abrami & Alexiane Decout & Michael Heymann & F. Gisou van der Goot & Gerardo Turcatti & Rayk Behrendt & Andrea Ablasser, 2018. "Targeting STING with covalent small-molecule inhibitors," Nature, Nature, vol. 559(7713), pages 269-273, July.
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