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NLRX1 is a regulator of mitochondrial antiviral immunity

Author

Listed:
  • Chris B. Moore

    (Department of Microbiology-Immunology,
    Lineberger Comprehensive Cancer Center,)

  • Daniel T. Bergstralh

    (Lineberger Comprehensive Cancer Center,)

  • Joseph A. Duncan

    (Department of Medicine, Division of Infectious Diseases)

  • Yu Lei

    (Department of Microbiology-Immunology,
    Lineberger Comprehensive Cancer Center,)

  • Thomas E. Morrison

    (Department of Genetics,
    Carolina Vaccine Institute,)

  • Albert G. Zimmermann

    (Department of Microbiology-Immunology,
    Lineberger Comprehensive Cancer Center,)

  • Mary A. Accavitti-Loper

    (University of Alabama at Birmingham, Birmingham, Alabama 35294, USA)

  • Victoria J. Madden

    (University of North Carolina, Chapel Hill, North Carolina 27599, USA)

  • Lijun Sun

    (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Zhengmao Ye

    (Department of Microbiology-Immunology,
    Lineberger Comprehensive Cancer Center,)

  • John D. Lich

    (Department of Microbiology-Immunology,
    Lineberger Comprehensive Cancer Center,)

  • Mark T. Heise

    (Department of Genetics,
    Carolina Vaccine Institute,)

  • Zhijian Chen

    (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Jenny P-Y. Ting

    (Department of Microbiology-Immunology,
    Lineberger Comprehensive Cancer Center,)

Abstract

Cytoplasmic RIG-like helicases are sensors of viral RNA, and signal through the mitochondrial adaptor protein MAVS to activate IRF3 and induce type 1 interferon production. This paper shows that a member of the NLR family of proteins called NLRX1 is a negative regulator of the pathway and functions by inhibiting the interaction of the viral sensor with the MAVS adaptor.

Suggested Citation

  • Chris B. Moore & Daniel T. Bergstralh & Joseph A. Duncan & Yu Lei & Thomas E. Morrison & Albert G. Zimmermann & Mary A. Accavitti-Loper & Victoria J. Madden & Lijun Sun & Zhengmao Ye & John D. Lich & , 2008. "NLRX1 is a regulator of mitochondrial antiviral immunity," Nature, Nature, vol. 451(7178), pages 573-577, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06501
    DOI: 10.1038/nature06501
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    Cited by:

    1. Joana Sá-Pessoa & Sara López-Montesino & Kornelia Przybyszewska & Isabel Rodríguez-Escudero & Helina Marshall & Adelia Ova & Gunnar N. Schroeder & Peter Barabas & María Molina & Tim Curtis & Víctor J., 2023. "A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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