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Mitochondrial form and function

Author

Listed:
  • Jonathan R. Friedman

    (College of Biological Sciences, University of California)

  • Jodi Nunnari

    (College of Biological Sciences, University of California)

Abstract

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

Suggested Citation

  • Jonathan R. Friedman & Jodi Nunnari, 2014. "Mitochondrial form and function," Nature, Nature, vol. 505(7483), pages 335-343, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7483:d:10.1038_nature12985
    DOI: 10.1038/nature12985
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    Cited by:

    1. Kangqiang Qiu & Weiwei Zou & Hongbao Fang & Mingang Hao & Kritika Mehta & Zhiqi Tian & Jun-Lin Guan & Kai Zhang & Taosheng Huang & Jiajie Diao, 2022. "Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Sun Woo Sophie Kang & Rory P. Cunningham & Colin B. Miller & Lauryn A. Brown & Constance M. Cultraro & Adam Harned & Kedar Narayan & Jonathan Hernandez & Lisa M. Jenkins & Alexei Lobanov & Maggie Cam , 2024. "A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Emma Puighermanal & Marta Luna-Sánchez & Alejandro Gella & Gunter van der Walt & Andrea Urpi & María Royo & Paula Tena-Morraja & Isabella Appiah & Maria Helena de Donato & Fabien Menardy & Patrizia Bi, 2024. "Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Eunah Kim & Andrea Annibal & Yujin Lee & Hae-Eun H. Park & Seokjin Ham & Dae-Eun Jeong & Younghun Kim & Sangsoon Park & Sujeong Kwon & Yoonji Jung & JiSoo Park & Sieun S. Kim & Adam Antebi & Seung-Jae, 2023. "Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Stephen M. Coscia & Andrew S. Moore & Cameron P. Thompson & Christian F. Tirrito & E. Michael Ostap & Erika L. F. Holzbaur, 2024. "An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Donghua Hu & Min Tan & Dongliang Lu & Brian Kleiboeker & Xuejing Liu & Hongsuk Park & Alexxai V. Kravitz & Kooresh I. Shoghi & Yu-Hua Tseng & Babak Razani & Akihiro Ikeda & Irfan J. Lodhi, 2023. "TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Yan Zou & Yajing Sun & Yibin Wang & Dongya Zhang & Huiqing Yang & Xin Wang & Meng Zheng & Bingyang Shi, 2023. "Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    8. Mathieu Ouellet & Gérald Guillebaud & Valerie Gervais & David Lupien St-Pierre & Marc Germain, 2017. "A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and inner membrane structure from confocal images," PLOS Computational Biology, Public Library of Science, vol. 13(6), pages 1-23, June.
    9. Shuaifeng Li & Shixun Han & Qi Zhang & Yibing Zhu & Haitao Zhang & Junli Wang & Yang Zhao & Jianhui Zhao & Lin Su & Li Li & Dawang Zhou & Cunqi Ye & Xin-Hua Feng & Tingbo Liang & Bin Zhao, 2022. "FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    10. Kanwar Abhay Singh & John Soukar & Mohammad Zulkifli & Anna Kersey & Giriraj Lokhande & Sagnika Ghosh & Aparna Murali & Natalie M. Garza & Harman Kaur & Justin N. Keeney & Ramu Banavath & Hatice Ceyla, 2024. "Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    11. Michael Webb & Jyoti Malhotra & Chui-Se Tham & Matthew Goddeeris & Douglas W McMillin & Effie Tozzo, 2017. "A Novel Mitophagy Assay for Skeletal Myotubes," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 4(4), pages 79-86, July.
    12. Scharf, Yael, 2017. "A chaotic outlook on biological systems," Chaos, Solitons & Fractals, Elsevier, vol. 95(C), pages 42-47.
    13. Joana Sá-Pessoa & Sara López-Montesino & Kornelia Przybyszewska & Isabel Rodríguez-Escudero & Helina Marshall & Adelia Ova & Gunnar N. Schroeder & Peter Barabas & María Molina & Tim Curtis & Víctor J., 2023. "A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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