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Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats

Author

Listed:
  • Miguel Angel Brieño-Enríquez

    (University of Pittsburgh
    University of Pittsburgh School of Medicine)

  • Mariela Faykoo-Martinez

    (University of Toronto
    University of Toronto, Mississauga
    The Hospital for Sick Children)

  • Meagan Goben

    (University of Pittsburgh)

  • Jennifer K. Grenier

    (Cornell University)

  • Ashley McGrath

    (Cornell University)

  • Alexandra M. Prado

    (Cornell University)

  • Jacob Sinopoli

    (Cornell University)

  • Kate Wagner

    (Cornell University)

  • Patrick T. Walsh

    (University of Pittsburgh)

  • Samia H. Lopa

    (University of Pittsburgh)

  • Diana J. Laird

    (University of California San Francisco)

  • Paula E. Cohen

    (Cornell University)

  • Michael D. Wilson

    (The Hospital for Sick Children
    University of Toronto)

  • Melissa M. Holmes

    (University of Toronto
    University of Toronto, Mississauga)

  • Ned J. Place

    (Cornell University)

Abstract

In the long-lived naked mole-rat (NMR), the entire process of oogenesis occurs postnatally. Germ cell numbers increase significantly in NMRs between postnatal days 5 (P5) and P8, and germs cells positive for proliferation markers (Ki-67, pHH3) are present at least until P90. Using pluripotency markers (SOX2 and OCT4) and the primordial germ cell (PGC) marker BLIMP1, we show that PGCs persist up to P90 alongside germ cells in all stages of female differentiation and undergo mitosis both in vivo and in vitro. We identified VASA+ SOX2+ cells at 6 months and at 3-years in subordinate and reproductively activated females. Reproductive activation was associated with proliferation of VASA+ SOX2+ cells. Collectively, our results suggest that highly desynchronized germ cell development and the maintenance of a small population of PGCs that can expand upon reproductive activation are unique strategies that could help to maintain the NMR’s ovarian reserve for its 30-year reproductive lifespan.

Suggested Citation

  • Miguel Angel Brieño-Enríquez & Mariela Faykoo-Martinez & Meagan Goben & Jennifer K. Grenier & Ashley McGrath & Alexandra M. Prado & Jacob Sinopoli & Kate Wagner & Patrick T. Walsh & Samia H. Lopa & Di, 2023. "Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36284-8
    DOI: 10.1038/s41467-023-36284-8
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