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A Validated Normative Model for Human Uterine Volume from Birth to Age 40 Years

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  • Thomas W Kelsey
  • Eleanor Ginbey
  • Moti M Chowdhury
  • Louise E Bath
  • Richard A Anderson
  • W Hamish B Wallace

Abstract

Transabdominal pelvic ultrasound and/or pelvic Magnetic Resonance Imaging are safe, accurate and non-invasive means of determining the size and configuration of the internal female genitalia. The assessment of uterine size and volume is helpful in the assessment of many conditions including disorders of sex development, precocious or delayed puberty, infertility and menstrual disorders. Using our own data from the assessment of MRI scans in healthy young females and data extracted from four studies that assessed uterine volume using transabdominal ultrasound in healthy females we have derived and validated a normative model of uterine volume from birth to age 40 years. This shows that uterine volume increases across childhood, with a faster increase in adolescence reflecting the influence of puberty, followed by a slow but progressive rise during adult life. The model suggests that around 84% of the variation in uterine volumes in the healthy population up to age 40 is due to age alone. The derivation of a validated normative model for uterine volume from birth to age 40 years has important clinical applications by providing age-related reference values for uterine volume.

Suggested Citation

  • Thomas W Kelsey & Eleanor Ginbey & Moti M Chowdhury & Louise E Bath & Richard A Anderson & W Hamish B Wallace, 2016. "A Validated Normative Model for Human Uterine Volume from Birth to Age 40 Years," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0157375
    DOI: 10.1371/journal.pone.0157375
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    References listed on IDEAS

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    1. W Hamish B Wallace & Thomas W Kelsey, 2010. "Human Ovarian Reserve from Conception to the Menopause," PLOS ONE, Public Library of Science, vol. 5(1), pages 1-9, January.
    2. Thomas W Kelsey & Lucy Q Li & Rod T Mitchell & Ashley Whelan & Richard A Anderson & W Hamish B Wallace, 2014. "A Validated Age-Related Normative Model for Male Total Testosterone Shows Increasing Variance but No Decline after Age 40 Years," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-11, October.
    3. Thomas W Kelsey & Amy Miles & Rod T Mitchell & Richard A Anderson & W Hamish B Wallace, 2016. "A Normative Model of Serum Inhibin B in Young Males," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-10, April.
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    Cited by:

    1. Tiffany Jones, 2018. "Intersex Studies: A Systematic Review of International Health Literature," SAGE Open, , vol. 8(2), pages 21582440177, May.

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