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Blimp1 is a critical determinant of the germ cell lineage in mice

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  • Yasuhide Ohinata

    (RIKEN Kobe Institute)

  • Bernhard Payer

    (University of Cambridge)

  • Dónal O'Carroll

    (The Laboratory for Lymphocyte Signaling)

  • Katia Ancelin

    (University of Cambridge)

  • Yukiko Ono

    (RIKEN Kobe Institute)

  • Mitsue Sano

    (RIKEN Kobe Institute)

  • Sheila C. Barton

    (University of Cambridge)

  • Tetyana Obukhanych

    (The Rockefeller University)

  • Michel Nussenzweig

    (The Rockefeller University)

  • Alexander Tarakhovsky

    (The Laboratory for Lymphocyte Signaling)

  • Mitinori Saitou

    (RIKEN Kobe Institute
    Japan Science and Technology Agency
    Kyoto University)

  • M. Azim Surani

    (University of Cambridge)

Abstract

Germ cell fate in mice is induced in pluripotent epiblast cells in response to signals from extraembryonic tissues. The specification of approximately 40 founder primordial germ cells and their segregation from somatic neighbours are important events in early development. We have proposed that a critical event during this specification includes repression of a somatic programme that is adopted by neighbouring cells. Here we show that Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation. Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the characteristic migration, proliferation and consistent repression of homeobox genes that normally accompany specification of primordial germ cells. Furthermore, our genetic lineage-tracing experiments indicate that the Blimp1-positive cells originating from the proximal posterior epiblast cells are indeed the lineage-restricted primordial germ cell precursors.

Suggested Citation

  • Yasuhide Ohinata & Bernhard Payer & Dónal O'Carroll & Katia Ancelin & Yukiko Ono & Mitsue Sano & Sheila C. Barton & Tetyana Obukhanych & Michel Nussenzweig & Alexander Tarakhovsky & Mitinori Saitou & , 2005. "Blimp1 is a critical determinant of the germ cell lineage in mice," Nature, Nature, vol. 436(7048), pages 207-213, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7048:d:10.1038_nature03813
    DOI: 10.1038/nature03813
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    Cited by:

    1. Shengyong Yu & Chunhua Zhou & Jiangping He & Zhaokai Yao & Xingnan Huang & Bowen Rong & Hong Zhu & Shijie Wang & Shuyan Chen & Xialian Wang & Baomei Cai & Guoqing Zhao & Yuhan Chen & Lizhan Xiao & He , 2022. "BMP4 drives primed to naïve transition through PGC-like state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Miguel Angel Brieño-Enríquez & Mariela Faykoo-Martinez & Meagan Goben & Jennifer K. Grenier & Ashley McGrath & Alexandra M. Prado & Jacob Sinopoli & Kate Wagner & Patrick T. Walsh & Samia H. Lopa & Di, 2023. "Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jiexiang Zhao & Ping Lu & Cong Wan & Yaping Huang & Manman Cui & Xinyan Yang & Yuqiong Hu & Yi Zheng & Ji Dong & Mei Wang & Shu Zhang & Zhaoting Liu & Shuhui Bian & Xiaoman Wang & Rui Wang & Shaofang , 2021. "Cell-fate transition and determination analysis of mouse male germ cells throughout development," Nature Communications, Nature, vol. 12(1), pages 1-20, December.

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