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High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

Author

Listed:
  • Xiao Tian

    (University of Rochester)

  • Jorge Azpurua

    (University of Rochester)

  • Christopher Hine

    (University of Rochester
    Present address: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.)

  • Amita Vaidya

    (University of Rochester)

  • Max Myakishev-Rempel

    (University of Rochester)

  • Julia Ablaeva

    (University of Rochester)

  • Zhiyong Mao

    (University of Rochester
    School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China)

  • Eviatar Nevo

    (Institute of Evolution, University of Haifa)

  • Vera Gorbunova

    (University of Rochester)

  • Andrei Seluanov

    (University of Rochester)

Abstract

Naked mole rats seem almost entirely protected from developing cancer, and this can now, at least in part, be explained by the production of a unique high-molecular-mass form of hyaluronan, a component of the extracellular matrix; together with an increased sensitivity of naked mole-rat cells to hyaluronan signalling, this form protects its cells from oncogenic transformation.

Suggested Citation

  • Xiao Tian & Jorge Azpurua & Christopher Hine & Amita Vaidya & Max Myakishev-Rempel & Julia Ablaeva & Zhiyong Mao & Eviatar Nevo & Vera Gorbunova & Andrei Seluanov, 2013. "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat," Nature, Nature, vol. 499(7458), pages 346-349, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7458:d:10.1038_nature12234
    DOI: 10.1038/nature12234
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    Citations

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    Cited by:

    1. Rong Hua & Yuan-Shuo Ma & Lu Yang & Jun-Jun Hao & Qin-Yang Hua & Lu-Ye Shi & Xiao-Qing Yao & Hao-Yu Zhi & Zhen Liu, 2024. "Experimental evidence for cancer resistance in a bat species," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Miguel Angel Brieño-Enríquez & Mariela Faykoo-Martinez & Meagan Goben & Jennifer K. Grenier & Ashley McGrath & Alexandra M. Prado & Jacob Sinopoli & Kate Wagner & Patrick T. Walsh & Samia H. Lopa & Di, 2023. "Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Guillem Sanchez Sanchez & Stephan Emmrich & Maria Georga & Ariadni Papadaki & Sofia Kossida & Andrei Seluanov & Vera Gorbunova & David Vermijlen, 2024. "Invariant γδTCR natural killer-like effector T cells in the naked mole-rat," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Shamir Montazid & Sheila Bandyopadhyay & Daniel W. Hart & Nan Gao & Brian Johnson & Sri G. Thrumurthy & Dustin J. Penn & Bettina Wernisch & Mukesh Bansal & Philipp M. Altrock & Fabian Rost & Patrycja , 2023. "Adult stem cell activity in naked mole rats for long-term tissue maintenance," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Michael Travisano & Michihisa Maeda & Fumie Fuji & Toshiaki Kudo, 2018. "Rapid adaptation to near extinction in microbial experimental evolution," Journal of Bioeconomics, Springer, vol. 20(1), pages 141-152, April.
    6. Tzuhua D. Lin & Nimrod D. Rubinstein & Nicole L. Fong & Megan Smith & Wendy Craft & Baby Martin-McNulty & Rebecca Perry & Martha A. Delaney & Margaret A. Roy & Rochelle Buffenstein, 2024. "Evolution of T cells in the cancer-resistant naked mole-rat," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    7. Yang Zhao & Zhizhong Zheng & Zhihui Zhang & Yandong Xu & Eric Hillpot & Yifei S. Lin & Frances T. Zakusilo & J. Yuyang Lu & Julia Ablaeva & Seyed Ali Biashad & Richard A. Miller & Eviatar Nevo & Andre, 2023. "Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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