IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45767-1.html
   My bibliography  Save this article

Experimental evidence for cancer resistance in a bat species

Author

Listed:
  • Rong Hua

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yuan-Shuo Ma

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lu Yang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jun-Jun Hao

    (Chinese Academy of Sciences)

  • Qin-Yang Hua

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lu-Ye Shi

    (Chinese Academy of Sciences)

  • Xiao-Qing Yao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Hao-Yu Zhi

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhen Liu

    (Chinese Academy of Sciences
    Yunnan Key Laboratory of Biodiversity Information)

Abstract

Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant to cancer due to their longevity, this has yet to be systematically examined. Here, we investigate cancer resistance across seven bat species by activating oncogenic genes in their primary cells. Both in vitro and in vivo experiments suggest that Myotis pilosus (MPI) is particularly resistant to cancer. The transcriptomic and functional analyses reveal that the downregulation of three genes (HIF1A, COPS5, and RPS3) largely contributes to cancer resistance in MPI. Further, we identify the loss of a potential enhancer containing the HIF1A binding site upstream of COPS5 in MPI, resulting in the downregulation of COPS5. These findings not only provide direct experimental evidence for cancer resistance in a bat species but also offer insights into the natural mechanisms of cancer resistance in mammals.

Suggested Citation

  • Rong Hua & Yuan-Shuo Ma & Lu Yang & Jun-Jun Hao & Qin-Yang Hua & Lu-Ye Shi & Xiao-Qing Yao & Hao-Yu Zhi & Zhen Liu, 2024. "Experimental evidence for cancer resistance in a bat species," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45767-1
    DOI: 10.1038/s41467-024-45767-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45767-1
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-45767-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Fazal Hadi & Yavuz Kulaberoglu & Kyren A. Lazarus & Karsten Bach & Rosemary Ugur & Paul Beattie & Ewan St John Smith & Walid T. Khaled, 2020. "Transformation of naked mole-rat cells," Nature, Nature, vol. 583(7814), pages 1-7, July.
    2. Inge Seim & Xiaodong Fang & Zhiqiang Xiong & Alexey V. Lobanov & Zhiyong Huang & Siming Ma & Yue Feng & Anton A. Turanov & Yabing Zhu & Tobias L. Lenz & Maxim V. Gerashchenko & Dingding Fan & Sun Hee , 2013. "Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii," Nature Communications, Nature, vol. 4(1), pages 1-8, October.
    3. Xiao Tian & Jorge Azpurua & Christopher Hine & Amita Vaidya & Max Myakishev-Rempel & Julia Ablaeva & Zhiyong Mao & Eviatar Nevo & Vera Gorbunova & Andrei Seluanov, 2013. "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat," Nature, Nature, vol. 499(7458), pages 346-349, July.
    4. Juliana G. Roscito & Katrin Sameith & Genis Parra & Bjoern E. Langer & Andreas Petzold & Claudia Moebius & Marc Bickle & Miguel Trefaut Rodrigues & Michael Hiller, 2018. "Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tzuhua D. Lin & Nimrod D. Rubinstein & Nicole L. Fong & Megan Smith & Wendy Craft & Baby Martin-McNulty & Rebecca Perry & Martha A. Delaney & Margaret A. Roy & Rochelle Buffenstein, 2024. "Evolution of T cells in the cancer-resistant naked mole-rat," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Guillem Sanchez Sanchez & Stephan Emmrich & Maria Georga & Ariadni Papadaki & Sofia Kossida & Andrei Seluanov & Vera Gorbunova & David Vermijlen, 2024. "Invariant γδTCR natural killer-like effector T cells in the naked mole-rat," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Mario Ivanković & Jeremias N. Brand & Luca Pandolfini & Thomas Brown & Martin Pippel & Andrei Rozanski & Til Schubert & Markus A. Grohme & Sylke Winkler & Laura Robledillo & Meng Zhang & Azzurra Codin, 2024. "A comparative analysis of planarian genomes reveals regulatory conservation in the face of rapid structural divergence," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Michael Travisano & Michihisa Maeda & Fumie Fuji & Toshiaki Kudo, 2018. "Rapid adaptation to near extinction in microbial experimental evolution," Journal of Bioeconomics, Springer, vol. 20(1), pages 141-152, April.
    5. Miguel Angel Brieño-Enríquez & Mariela Faykoo-Martinez & Meagan Goben & Jennifer K. Grenier & Ashley McGrath & Alexandra M. Prado & Jacob Sinopoli & Kate Wagner & Patrick T. Walsh & Samia H. Lopa & Di, 2023. "Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Yang Zhao & Zhizhong Zheng & Zhihui Zhang & Yandong Xu & Eric Hillpot & Yifei S. Lin & Frances T. Zakusilo & J. Yuyang Lu & Julia Ablaeva & Seyed Ali Biashad & Richard A. Miller & Eviatar Nevo & Andre, 2023. "Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Shamir Montazid & Sheila Bandyopadhyay & Daniel W. Hart & Nan Gao & Brian Johnson & Sri G. Thrumurthy & Dustin J. Penn & Bettina Wernisch & Mukesh Bansal & Philipp M. Altrock & Fabian Rost & Patrycja , 2023. "Adult stem cell activity in naked mole rats for long-term tissue maintenance," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45767-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.