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Experimental evidence for cancer resistance in a bat species

Author

Listed:
  • Rong Hua

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yuan-Shuo Ma

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lu Yang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jun-Jun Hao

    (Chinese Academy of Sciences)

  • Qin-Yang Hua

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Lu-Ye Shi

    (Chinese Academy of Sciences)

  • Xiao-Qing Yao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Hao-Yu Zhi

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhen Liu

    (Chinese Academy of Sciences
    Yunnan Key Laboratory of Biodiversity Information)

Abstract

Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant to cancer due to their longevity, this has yet to be systematically examined. Here, we investigate cancer resistance across seven bat species by activating oncogenic genes in their primary cells. Both in vitro and in vivo experiments suggest that Myotis pilosus (MPI) is particularly resistant to cancer. The transcriptomic and functional analyses reveal that the downregulation of three genes (HIF1A, COPS5, and RPS3) largely contributes to cancer resistance in MPI. Further, we identify the loss of a potential enhancer containing the HIF1A binding site upstream of COPS5 in MPI, resulting in the downregulation of COPS5. These findings not only provide direct experimental evidence for cancer resistance in a bat species but also offer insights into the natural mechanisms of cancer resistance in mammals.

Suggested Citation

  • Rong Hua & Yuan-Shuo Ma & Lu Yang & Jun-Jun Hao & Qin-Yang Hua & Lu-Ye Shi & Xiao-Qing Yao & Hao-Yu Zhi & Zhen Liu, 2024. "Experimental evidence for cancer resistance in a bat species," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45767-1
    DOI: 10.1038/s41467-024-45767-1
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    References listed on IDEAS

    as
    1. Inge Seim & Xiaodong Fang & Zhiqiang Xiong & Alexey V. Lobanov & Zhiyong Huang & Siming Ma & Yue Feng & Anton A. Turanov & Yabing Zhu & Tobias L. Lenz & Maxim V. Gerashchenko & Dingding Fan & Sun Hee , 2013. "Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii," Nature Communications, Nature, vol. 4(1), pages 1-8, October.
    2. Xiao Tian & Jorge Azpurua & Christopher Hine & Amita Vaidya & Max Myakishev-Rempel & Julia Ablaeva & Zhiyong Mao & Eviatar Nevo & Vera Gorbunova & Andrei Seluanov, 2013. "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat," Nature, Nature, vol. 499(7458), pages 346-349, July.
    3. Fazal Hadi & Yavuz Kulaberoglu & Kyren A. Lazarus & Karsten Bach & Rosemary Ugur & Paul Beattie & Ewan St John Smith & Walid T. Khaled, 2020. "Transformation of naked mole-rat cells," Nature, Nature, vol. 583(7814), pages 1-7, July.
    4. Juliana G. Roscito & Katrin Sameith & Genis Parra & Bjoern E. Langer & Andreas Petzold & Claudia Moebius & Marc Bickle & Miguel Trefaut Rodrigues & Michael Hiller, 2018. "Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
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