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Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine

Author

Listed:
  • Guoyin Chen

    (Donghua University)

  • Kai Hou

    (Donghua University)

  • Nuo Yu

    (Donghua University)

  • Peiling Wei

    (Donghua University)

  • Tao Chen

    (Donghua University)

  • Caihong Zhang

    (Donghua University)

  • Shun Wang

    (Donghua University)

  • Hongmei Liu

    (Donghua University)

  • Ran Cao

    (Donghua University)

  • Liping Zhu

    (Donghua University)

  • Benjamin S. Hsiao

    (Donghua University
    Stony Brook University)

  • Meifang Zhu

    (Donghua University)

Abstract

Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing to the limited penetration of light and difficult monitoring of the photo-media therapies, it is challenging to apply photomedical treatment in deep tissue as they may damage normal tissues. Herein, a thermal regulated interventional photomedicine based on a temperature-adaptive hydrogel fiber-based optical waveguide (THFOW) is proposed, capable of eliminating deeply seated tumor cells while lowering risks of overtemperature (causes the death of healthy cells around the tumor). The THFOW is fabricated by an integrated homogeneous-dynamic-crosslinking-spinning method, and shows a remarkable soft tissue-affinity (low cytotoxicity, swelling stability, and soft tissue-like Young’s modulus). Moreover, the THFOW shows an excellent light propagation property with different wavenumbers (especially −0.32 dB cm−1 with 915 nm laser light), and temperature-gated light propagation effect. The THFOW and relevant therapeutic strategy offer a promising application for intelligent photomedicine in deep issue.

Suggested Citation

  • Guoyin Chen & Kai Hou & Nuo Yu & Peiling Wei & Tao Chen & Caihong Zhang & Shun Wang & Hongmei Liu & Ran Cao & Liping Zhu & Benjamin S. Hsiao & Meifang Zhu, 2022. "Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35440-w
    DOI: 10.1038/s41467-022-35440-w
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    1. Jeong-Yun Sun & Xuanhe Zhao & Widusha R. K. Illeperuma & Ovijit Chaudhuri & Kyu Hwan Oh & David J. Mooney & Joost J. Vlassak & Zhigang Suo, 2012. "Highly stretchable and tough hydrogels," Nature, Nature, vol. 489(7414), pages 133-136, September.
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