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Basal forebrain projections to the lateral habenula modulate aggression reward

Author

Listed:
  • Sam A. Golden

    (Icahn School of Medicine at Mount Sinai
    Graduate Program in Neuroscience, Icahn School of Medicine at Mount Sinai)

  • Mitra Heshmati

    (Icahn School of Medicine at Mount Sinai
    Graduate Program in Neuroscience, Icahn School of Medicine at Mount Sinai)

  • Meghan Flanigan

    (Icahn School of Medicine at Mount Sinai
    Graduate Program in Neuroscience, Icahn School of Medicine at Mount Sinai)

  • Daniel J. Christoffel

    (Stanford University Medical Center)

  • Kevin Guise

    (Icahn School of Medicine at Mount Sinai
    Graduate Program in Neuroscience, Icahn School of Medicine at Mount Sinai)

  • Madeline L. Pfau

    (Icahn School of Medicine at Mount Sinai
    Graduate Program in Neuroscience, Icahn School of Medicine at Mount Sinai)

  • Hossein Aleyasin

    (Icahn School of Medicine at Mount Sinai)

  • Caroline Menard

    (Icahn School of Medicine at Mount Sinai)

  • Hongxing Zhang

    (Pharmacology and Systems Therapeutics and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai)

  • Georgia E. Hodes

    (Icahn School of Medicine at Mount Sinai)

  • Dana Bregman

    (Icahn School of Medicine at Mount Sinai)

  • Lena Khibnik

    (Icahn School of Medicine at Mount Sinai)

  • Jonathan Tai

    (Icahn School of Medicine at Mount Sinai)

  • Nicole Rebusi

    (Icahn School of Medicine at Mount Sinai)

  • Brian Krawitz

    (Icahn School of Medicine at Mount Sinai
    Graduate Program in Neuroscience, Icahn School of Medicine at Mount Sinai)

  • Dipesh Chaudhury

    (Pharmacology and Systems Therapeutics and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai)

  • Jessica J. Walsh

    (Stanford University Medical Center)

  • Ming-Hu Han

    (Icahn School of Medicine at Mount Sinai
    Pharmacology and Systems Therapeutics and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai)

  • Matt L. Shapiro

    (Icahn School of Medicine at Mount Sinai)

  • Scott J. Russo

    (Icahn School of Medicine at Mount Sinai)

Abstract

Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal forebrain to the lateral habenula bi-directionally controls this aspect of aggression.

Suggested Citation

  • Sam A. Golden & Mitra Heshmati & Meghan Flanigan & Daniel J. Christoffel & Kevin Guise & Madeline L. Pfau & Hossein Aleyasin & Caroline Menard & Hongxing Zhang & Georgia E. Hodes & Dana Bregman & Lena, 2016. "Basal forebrain projections to the lateral habenula modulate aggression reward," Nature, Nature, vol. 534(7609), pages 688-692, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7609:d:10.1038_nature18601
    DOI: 10.1038/nature18601
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    Citations

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    Cited by:

    1. Hiroyuki Kawai & Youcef Bouchekioua & Naoya Nishitani & Kazuhei Niitani & Shoma Izumi & Hinako Morishita & Chihiro Andoh & Yuma Nagai & Masashi Koda & Masako Hagiwara & Koji Toda & Hisashi Shirakawa &, 2022. "Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Aki Takahashi & Romain Durand-de Cuttoli & Meghan E. Flanigan & Emi Hasegawa & Tomomi Tsunematsu & Hossein Aleyasin & Yoan Cherasse & Ken Miya & Takuya Okada & Kazuko Keino-Masu & Koshiro Mitsui & Lon, 2022. "Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Darshini Mahadevia & Rinki Saha & Alessia Manganaro & Nao Chuhma & Annette Ziolkowski-Blake & Ashlea A. Morgan & Dani Dumitriu & Stephen Rayport & Mark S. Ansorge, 2021. "Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Jun Wang & Qian Yang & Xue Liu & Jie Li & Ya-Lan Wen & Yuzheng Hu & Tian-Le Xu & Shumin Duan & Han Xu, 2024. "The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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