IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms10503.html
   My bibliography  Save this article

Serotonin neurons in the dorsal raphe nucleus encode reward signals

Author

Listed:
  • Yi Li

    (Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences
    National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Weixin Zhong

    (Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences
    National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Daqing Wang

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China
    School of Life Sciences, Tsinghua University)

  • Qiru Feng

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Zhixiang Liu

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Jingfeng Zhou

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China
    PTN Graduate Program, School of Life Sciences, Peking University)

  • Chunying Jia

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Fei Hu

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Jiawei Zeng

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China)

  • Qingchun Guo

    (National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China
    Wuhan National Laboratory for Optoelectronics-Huazhong, Britton Chance Center for Biomedical Photonics, University of Science and Technology)

  • Ling Fu

    (Wuhan National Laboratory for Optoelectronics-Huazhong, Britton Chance Center for Biomedical Photonics, University of Science and Technology)

  • Minmin Luo

    (Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences
    National Institute of Biological Sciences, Zhongguancun Life Science Park 7 Science Park Road, Beijing 102206, China
    School of Life Sciences, Tsinghua University)

Abstract

The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours; however, it remains unclear how genetically defined neurons in the DRN of a freely behaving animal respond to various natural rewards. Here we addressed this question using fibre photometry and single-unit recording from serotonin (5-HT) neurons and GABA neurons in the DRN of behaving mice. Rewards including sucrose, food, sex and social interaction rapidly activate 5-HT neurons, but aversive stimuli including quinine and footshock do not. Both expected and unexpected rewards activate 5-HT neurons. After mice learn to wait for sucrose delivery, most 5-HT neurons fire tonically during waiting and then phasically on reward acquisition. Finally, GABA neurons are activated by aversive stimuli but inhibited when mice seek rewards. Thus, DRN 5-HT neurons positively encode a wide range of reward signals during anticipatory and consummatory phases of reward responses. Moreover, GABA neurons play a complementary role in reward processing.

Suggested Citation

  • Yi Li & Weixin Zhong & Daqing Wang & Qiru Feng & Zhixiang Liu & Jingfeng Zhou & Chunying Jia & Fei Hu & Jiawei Zeng & Qingchun Guo & Ling Fu & Minmin Luo, 2016. "Serotonin neurons in the dorsal raphe nucleus encode reward signals," Nature Communications, Nature, vol. 7(1), pages 1-15, April.
  • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10503
    DOI: 10.1038/ncomms10503
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10503
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/ncomms10503?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jing Huang & Weijun Huang & Junzhe Yi & Yiwen Deng & Ruijie Li & Jieying Chen & Jiahao Shi & Yuan Qiu & Tao Wang & Xiaoyong Chen & Xiaoran Zhang & Andy Peng Xiang, 2023. "Mesenchymal stromal cells alleviate depressive and anxiety-like behaviors via a lung vagal-to-brain axis in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Weihua Ding & Liuyue Yang & Eleanor Shi & Bowon Kim & Sarah Low & Kun Hu & Lei Gao & Ping Chen & Wei Ding & David Borsook & Andrew Luo & Jee Hyun Choi & Changning Wang & Oluwaseun Akeju & Jun Yang & C, 2023. "The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Weiwei Guo & Sijia Fan & Dan Xiao & Hui Dong & Guangwei Xu & Zhikun Wan & Yuqian Ma & Zhen Wang & Tian Xue & Yifeng Zhou & Yulong Li & Wei Xiong, 2021. "A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Hiroyuki Kawai & Youcef Bouchekioua & Naoya Nishitani & Kazuhei Niitani & Shoma Izumi & Hinako Morishita & Chihiro Andoh & Yuma Nagai & Masashi Koda & Masako Hagiwara & Koji Toda & Hisashi Shirakawa &, 2022. "Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    5. Huanyuan Zhou & KongFatt Wong-Lin & Da-Hui Wang, 2018. "Parallel Excitatory and Inhibitory Neural Circuit Pathways Underlie Reward-Based Phasic Neural Responses," Complexity, Hindawi, vol. 2018, pages 1-20, April.
    6. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Shuancheng Ren & Cai Zhang & Faguo Yue & Jinxiang Tang & Wei Zhang & Yue Zheng & Yuanyuan Fang & Na Wang & Zhenbo Song & Zehui Zhang & Xiaolong Zhang & Han Qin & Yaling Wang & Jianxia Xia & Chenggang , 2024. "A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Yan Zhang & Jiayi Shen & Famin Xie & Zhiwei Liu & Fangfang Yin & Mingxiu Cheng & Liang Wang & Meiting Cai & Herbert Herzog & Ping Wu & Zhi Zhang & Cheng Zhan & Tiemin Liu, 2024. "Feedforward inhibition of stress by brainstem neuropeptide Y neurons," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    9. Hiro Taiyo Hamada & Yoshifumi Abe & Norio Takata & Masakazu Taira & Kenji F. Tanaka & Kenji Doya, 2024. "Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Li Shen & Guang-Wei Zhang & Can Tao & Michelle B. Seo & Nicole K. Zhang & Junxiang J. Huang & Li I. Zhang & Huizhong W. Tao, 2022. "A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    11. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    12. Seth R. Batten & Dan Bang & Brian H. Kopell & Arianna N. Davis & Matthew Heflin & Qixiu Fu & Ofer Perl & Kimia Ziafat & Alice Hashemi & Ignacio Saez & Leonardo S. Barbosa & Thomas Twomey & Terry Lohre, 2024. "Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange," Nature Human Behaviour, Nature, vol. 8(4), pages 718-728, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10503. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.