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Lateral habenula as a source of negative reward signals in dopamine neurons

Author

Listed:
  • Masayuki Matsumoto

    (Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435, USA)

  • Okihide Hikosaka

    (Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435, USA)

Abstract

Rewarding behaviour The involvement of dopaminergic neurons in motor symptoms is evident from their role in Parkinson's disease. Yet the neurons that release dopamine carry signals related to rewards, not body movements. As a solution to this puzzle, recent theories suggest that the reward-related dopamine signals are used for learning of motor behaviours. Until now it has been unclear how dopamine neurons acquire the reward-related signals. Now in an experiment in rhesus monkeys performing a visually guided task for reward, Masayuki Matsumoto and Okihide Hikosaka show that a small brain area called the lateral habenula controls dopamine neurons by inhibiting them and thereby suppressing less rewarding eye movements. This discovery opens up possibilities for new research on the links between emotion, motivation and motor behaviours.

Suggested Citation

  • Masayuki Matsumoto & Okihide Hikosaka, 2007. "Lateral habenula as a source of negative reward signals in dopamine neurons," Nature, Nature, vol. 447(7148), pages 1111-1115, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7148:d:10.1038_nature05860
    DOI: 10.1038/nature05860
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    Cited by:

    1. Soo Hyun Yang & Esther Yang & Jaekwang Lee & Jin Yong Kim & Hyeijung Yoo & Hyung Sun Park & Jin Taek Jung & Dongmin Lee & Sungkun Chun & Yong Sang Jo & Gyeong Hee Pyeon & Jae-Yong Park & Hyun Woo Lee , 2023. "Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Robert C Wilson & Matthew R Nassar & Joshua I Gold, 2013. "A Mixture of Delta-Rules Approximation to Bayesian Inference in Change-Point Problems," PLOS Computational Biology, Public Library of Science, vol. 9(7), pages 1-18, July.
    3. Maggie W. Waung & Kayla A. Maanum & Thomas J. Cirino & Joseph R. Driscoll & Chris O’Brien & Svetlana Bryant & Kasra A. Mansourian & Marisela Morales & David J. Barker & Elyssa B. Margolis, 2022. "A diencephalic circuit in rats for opioid analgesia but not positive reinforcement," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Hiroyuki Kawai & Youcef Bouchekioua & Naoya Nishitani & Kazuhei Niitani & Shoma Izumi & Hinako Morishita & Chihiro Andoh & Yuma Nagai & Masashi Koda & Masako Hagiwara & Koji Toda & Hisashi Shirakawa &, 2022. "Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    5. Tommaso Ianni & Sedona N. Ewbank & Marjorie R. Levinstein & Matine M. Azadian & Reece C. Budinich & Michael Michaelides & Raag D. Airan, 2024. "Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Anton Ilango & Jason Shumake & Wolfram Wetzel & Henning Scheich & Frank W Ohl, 2013. "Electrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Response," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    7. Huanyuan Zhou & KongFatt Wong-Lin & Da-Hui Wang, 2018. "Parallel Excitatory and Inhibitory Neural Circuit Pathways Underlie Reward-Based Phasic Neural Responses," Complexity, Hindawi, vol. 2018, pages 1-20, April.
    8. Robyn Mary Brown & Jennifer Lynn Short & Andrew John Lawrence, 2010. "Identification of Brain Nuclei Implicated in Cocaine-Primed Reinstatement of Conditioned Place Preference: A Behaviour Dissociable from Sensitization," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-13, December.
    9. Paul Leon Brown & Paul D Shepard, 2013. "Lesions of the Fasciculus Retroflexus Alter Footshock-Induced cFos Expression in the Mesopontine Rostromedial Tegmental Area of Rats," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.
    10. Li Shen & Guang-Wei Zhang & Can Tao & Michelle B. Seo & Nicole K. Zhang & Junxiang J. Huang & Li I. Zhang & Huizhong W. Tao, 2022. "A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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