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Diverging neural pathways assemble a behavioural state from separable features in anxiety

Author

Listed:
  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Avishek Adhikari

    (Stanford University)

  • Soo Yeun Lee

    (Stanford University
    CNC Program, Stanford University)

  • James H. Marshel

    (Stanford University)

  • Christina K. Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Caitlin S. Mallory

    (Stanford University
    Neurosciences Program, Stanford University)

  • Maisie Lo

    (Stanford University)

  • Sally Pak

    (Stanford University)

  • Joanna Mattis

    (Stanford University
    Neurosciences Program, Stanford University)

  • Byung Kook Lim

    (Stanford University)

  • Robert C. Malenka

    (Stanford University)

  • Melissa R. Warden

    (Stanford University)

  • Rachael Neve

    (Massachusetts Institute of Technology)

  • Kay M. Tye

    (Stanford University
    Massachusetts Institute of Technology)

  • Karl Deisseroth

    (Stanford University
    Neurosciences Program, Stanford University
    CNC Program, Stanford University
    Stanford University)

Abstract

Different subregions of the bed nucleus of the stria terminalis are shown to increase and decrease anxiety in mice, and distinct neural projections arising from a single coordinating brain region modulate different anxiety features.

Suggested Citation

  • Sung-Yon Kim & Avishek Adhikari & Soo Yeun Lee & James H. Marshel & Christina K. Kim & Caitlin S. Mallory & Maisie Lo & Sally Pak & Joanna Mattis & Byung Kook Lim & Robert C. Malenka & Melissa R. Ward, 2013. "Diverging neural pathways assemble a behavioural state from separable features in anxiety," Nature, Nature, vol. 496(7444), pages 219-223, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7444:d:10.1038_nature12018
    DOI: 10.1038/nature12018
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    Cited by:

    1. Robert N. Fetcho & Baila S. Hall & David J. Estrin & Alexander P. Walsh & Peter J. Schuette & Jesse Kaminsky & Ashna Singh & Jacob Roshgodal & Charlotte C. Bavley & Viraj Nadkarni & Susan Antigua & Th, 2023. "Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Stephan Dodt & Noah V. Widdershooven & Marie-Luise Dreisow & Lisa Weiher & Lukas Steuernagel & F. Thomas Wunderlich & Jens C. Brüning & Henning Fenselau, 2024. "NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Ren-Wen Han & Zi-Yi Zhang & Chen Jiao & Ze-Yu Hu & Bing-Xing Pan, 2024. "Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Jing-Jing Yan & Xiao-Jing Ding & Ting He & Ai-Xiao Chen & Wen Zhang & Zi-Xian Yu & Xin-Yu Cheng & Chuan-Yao Wei & Qiao-Dan Hu & Xiao-Yao Liu & Yan-Li Zhang & Mengge He & Zhi-Yong Xie & Xi Zha & Chun X, 2022. "A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Anna J. Bowen & Y. Waterlily Huang & Jane Y. Chen & Jordan L. Pauli & Carlos A. Campos & Richard D. Palmiter, 2023. "Topographic representation of current and future threats in the mouse nociceptive amygdala," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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