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A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

Author

Listed:
  • Carl-Philipp Hackstein

    (University of Oxford
    University of Oxford)

  • Dana Costigan

    (University of Oxford)

  • Linnea Drexhage

    (University of Oxford
    University of Oxford)

  • Claire Pearson

    (University of Oxford)

  • Samuel Bullers

    (University of Oxford)

  • Nicholas Ilott

    (University of Oxford)

  • Hossain Delowar Akther

    (University of Oxford
    University of Oxford)

  • Yisu Gu

    (University of Oxford)

  • Michael E. B. FitzPatrick

    (University of Oxford)

  • Oliver J. Harrison

    (Benaroya Research Institute
    University of Washington)

  • Lucy C. Garner

    (University of Oxford)

  • Elizabeth H. Mann

    (University of Oxford)

  • Sumeet Pandey

    (University of Oxford)

  • Matthias Friedrich

    (University of Oxford
    University of Oxford)

  • Nicholas M. Provine

    (University of Oxford)

  • Holm H. Uhlig

    (University of Oxford)

  • Emanuele Marchi

    (University of Oxford)

  • Fiona Powrie

    (University of Oxford)

  • Paul Klenerman

    (University of Oxford
    University of Oxford)

  • Emily E. Thornton

    (University of Oxford
    University of Oxford
    University of Oxford)

Abstract

Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling, antigen-specific T cells are poised to respond to local insults, making their phenotype important in the relationship between host and microbes. Here we show that MHC-II restricted, commensal-reactive T cells in the colon of both humans and mice acquire transcriptional and functional characteristics associated with innate-like T cells. This cell population is abundant and conserved in the human and murine colon and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis. T cells with this phenotype are increased in ulcerative colitis patients, and their presence aggravates pathology in dextran sodium sulphate-treated mice, pointing towards a pathogenic role in colitis. Our findings add to the expanding spectrum of innate-like immune cells positioned at the frontline of intestinal immune surveillance, capable of acting as sentinels of microbes and the local cytokine milieu.

Suggested Citation

  • Carl-Philipp Hackstein & Dana Costigan & Linnea Drexhage & Claire Pearson & Samuel Bullers & Nicholas Ilott & Hossain Delowar Akther & Yisu Gu & Michael E. B. FitzPatrick & Oliver J. Harrison & Lucy C, 2022. "A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35126-3
    DOI: 10.1038/s41467-022-35126-3
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    References listed on IDEAS

    as
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