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Peripheral education of the immune system by colonic commensal microbiota

Author

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  • Stephanie K. Lathrop

    (Washington University School of Medicine
    Present addresses: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840, USA (S.K.L.); Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA (D.A.P.).)

  • Seth M. Bloom

    (Washington University School of Medicine)

  • Sindhuja M. Rao

    (Washington University School of Medicine)

  • Katherine Nutsch

    (Washington University School of Medicine)

  • Chan-Wang Lio

    (Washington University School of Medicine)

  • Nicole Santacruz

    (Washington University School of Medicine)

  • Daniel A. Peterson

    (University of Nebraska-Lincoln
    Present addresses: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840, USA (S.K.L.); Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA (D.A.P.).)

  • Thaddeus S. Stappenbeck

    (Washington University School of Medicine)

  • Chyi-Song Hsieh

    (Washington University School of Medicine)

Abstract

Learning to tolerate friendly bacteria Understanding how the immune system becomes tolerant to foreign antigens from commensal bacteria is a fundamental question, as breakdown of tolerance can result in unwanted responses such as inflammatory bowel disease. It has been suggested that tolerogenic regulatory T (Treg) cells are generated in response to commensal bacteria, but there is little direct evidence to support this hypothesis. A study of the colonic T-cell antigen receptor repertoire of mice now shows that microbial antigens direct the generation of antigen-specific inducible Treg cells in the colon. Commensal-induced Treg cells seem to maintain mucosal tolerance and protect mice from colitis.

Suggested Citation

  • Stephanie K. Lathrop & Seth M. Bloom & Sindhuja M. Rao & Katherine Nutsch & Chan-Wang Lio & Nicole Santacruz & Daniel A. Peterson & Thaddeus S. Stappenbeck & Chyi-Song Hsieh, 2011. "Peripheral education of the immune system by colonic commensal microbiota," Nature, Nature, vol. 478(7368), pages 250-254, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_nature10434
    DOI: 10.1038/nature10434
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    Cited by:

    1. Aaron C Ericsson & J Wade Davis & William Spollen & Nathan Bivens & Scott Givan & Catherine E Hagan & Mark McIntosh & Craig L Franklin, 2015. "Effects of Vendor and Genetic Background on the Composition of the Fecal Microbiota of Inbred Mice," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-19, February.
    2. Carl-Philipp Hackstein & Dana Costigan & Linnea Drexhage & Claire Pearson & Samuel Bullers & Nicholas Ilott & Hossain Delowar Akther & Yisu Gu & Michael E. B. FitzPatrick & Oliver J. Harrison & Lucy C, 2022. "A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Kang Li & Zeng Dan & Luobu Gesang & Hong Wang & Yongjian Zhou & Yanlei Du & Yi Ren & Yixiang Shi & Yuqiang Nie, 2016. "Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-16, May.

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