IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v554y2018i7692d10.1038_nature25500.html
   My bibliography  Save this article

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Author

Listed:
  • Mo Xu

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Maria Pokrovskii

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Yi Ding

    (University of Rochester Medical Center)

  • Ren Yi

    (Courant Institute of Mathematical Sciences, New York University)

  • Christy Au

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    The Howard Hughes Medical Institute, New York University School of Medicine)

  • Oliver J. Harrison

    (Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH)

  • Carolina Galan

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Yasmine Belkaid

    (Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH
    NIAID Microbiome Program, NIH)

  • Richard Bonneau

    (Courant Institute of Mathematical Sciences, New York University
    Center for Genomics and Systems Biology, New York University
    Center for Computational Biology, Flatiron Institute, Simons Foundation)

  • Dan R. Littman

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    The Howard Hughes Medical Institute, New York University School of Medicine)

Abstract

The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory TH17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.

Suggested Citation

  • Mo Xu & Maria Pokrovskii & Yi Ding & Ren Yi & Christy Au & Oliver J. Harrison & Carolina Galan & Yasmine Belkaid & Richard Bonneau & Dan R. Littman, 2018. "c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont," Nature, Nature, vol. 554(7692), pages 373-377, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25500
    DOI: 10.1038/nature25500
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25500
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25500?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhaoyun Ding & Ting Cai & Jupei Tang & Hanxiao Sun & Xinyi Qi & Yunpeng Zhang & Yan Ji & Liyun Yuan & Huidan Chang & Yanhui Ma & Hong Zhou & Li Li & Huiming Sheng & Ju Qiu, 2022. "Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Carl-Philipp Hackstein & Dana Costigan & Linnea Drexhage & Claire Pearson & Samuel Bullers & Nicholas Ilott & Hossain Delowar Akther & Yisu Gu & Michael E. B. FitzPatrick & Oliver J. Harrison & Lucy C, 2022. "A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Jinchun Wu & Yang Liu & Liqiong Ou & Tingting Gan & Zhengrong Zhangding & Shaopeng Yuan & Xinyi Liu & Mengzhu Liu & Jiasheng Li & Jianhang Yin & Changchang Xin & Ye Tian & Jiazhi Hu, 2024. "Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Nguyen T. Van & Karen Zhang & Rachel M. Wigmore & Anne I. Kennedy & Carolina R. DaSilva & Jialing Huang & Manju Ambelil & Jose H. Villagomez & Gerald J. O’Connor & Randy S. Longman & Miao Cao & Adam E, 2023. "Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Channakeshava Sokke Umeshappa & Patricia Solé & Jun Yamanouchi & Saswat Mohapatra & Bas G. J. Surewaard & Josep Garnica & Santiswarup Singha & Debajyoti Mondal & Elena Cortés-Vicente & Charlotte D’Mel, 2022. "Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    6. Lizhen Zhu & Geng Li & Zhixin Liang & Tuan Qi & Kui Deng & Jiancheng Yu & Yue Peng & Jusheng Zheng & Yan Song & Xing Chang, 2023. "Microbiota-assisted iron uptake promotes immune tolerance in the intestine," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25500. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.