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Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

Author

Listed:
  • J. Justin Milner

    (University of California, San Diego)

  • Clara Toma

    (University of California, San Diego)

  • Bingfei Yu

    (University of California, San Diego)

  • Kai Zhang

    (Bioinformatics and Systems Biology Graduate Program, University of California, San Diego)

  • Kyla Omilusik

    (University of California, San Diego)

  • Anthony T. Phan

    (University of California, San Diego)

  • Dapeng Wang

    (The Scripps Research Institute)

  • Adam J. Getzler

    (The Scripps Research Institute)

  • Toan Nguyen

    (University of California, San Diego)

  • Shane Crotty

    (La Jolla Institute for Allergy and Immunology
    University of California, San Diego)

  • Wei Wang

    (Bioinformatics and Systems Biology Graduate Program, University of California, San Diego
    University of California, San Diego
    University of California, San Diego)

  • Matthew E. Pipkin

    (The Scripps Research Institute)

  • Ananda W. Goldrath

    (University of California, San Diego)

Abstract

The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8+ T cells, providing insights into the signals that promote T cell residency in non-lymphoid tissues and tumours.

Suggested Citation

  • J. Justin Milner & Clara Toma & Bingfei Yu & Kai Zhang & Kyla Omilusik & Anthony T. Phan & Dapeng Wang & Adam J. Getzler & Toan Nguyen & Shane Crotty & Wei Wang & Matthew E. Pipkin & Ananda W. Goldrat, 2017. "Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours," Nature, Nature, vol. 552(7684), pages 253-257, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7684:d:10.1038_nature24993
    DOI: 10.1038/nature24993
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    Cited by:

    1. Alexandria C. Wells & Kaito A. Hioki & Constance C. Angelou & Adam C. Lynch & Xueting Liang & Daniel J. Ryan & Iris Thesmar & Saule Zhanybekova & Saulius Zuklys & Jacob Ullom & Agnes Cheong & Jesse Ma, 2023. "Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Carl-Philipp Hackstein & Dana Costigan & Linnea Drexhage & Claire Pearson & Samuel Bullers & Nicholas Ilott & Hossain Delowar Akther & Yisu Gu & Michael E. B. FitzPatrick & Oliver J. Harrison & Lucy C, 2022. "A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Curtis J. Pritzl & Dezzarae Luera & Karin M. Knudson & Michael J. Quaney & Michael J. Calcutt & Mark A. Daniels & Emma Teixeiro, 2023. "IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Bogang Wu & Xiaowen Zhang & Huai-Chin Chiang & Haihui Pan & Bin Yuan & Payal Mitra & Leilei Qi & Hayk Simonyan & Colin N. Young & Eric Yvon & Yanfen Hu & Nu Zhang & Rong Li, 2022. "RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Richard I. Ainsworth & Deepa Hammaker & Gyrid Nygaard & Cecilia Ansalone & Camilla Machado & Kai Zhang & Lina Zheng & Lucy Carrillo & Andre Wildberg & Amanda Kuhs & Mattias N. D. Svensson & David L. B, 2022. "Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Yuan Liao & Lifeng Ma & Qile Guo & Weigao E & Xing Fang & Lei Yang & Fanwei Ruan & Jingjing Wang & Peijing Zhang & Zhongyi Sun & Haide Chen & Zhongliang Lin & Xueyi Wang & Xinru Wang & Huiyu Sun & Xiu, 2022. "Cell landscape of larval and adult Xenopus laevis at single-cell resolution," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Guo Li & Saranya Srinivasan & Liwen Wang & Chaoyu Ma & Kai Guo & Wenhao Xiao & Wei Liao & Shruti Mishra & Xin Zhang & Yuanzheng Qiu & Qianjin Lu & Yong Liu & Nu Zhang, 2022. "TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Matteo Villa & David E. Sanin & Petya Apostolova & Mauro Corrado & Agnieszka M. Kabat & Carmine Cristinzio & Annamaria Regina & Gustavo E. Carrizo & Nisha Rana & Michal A. Stanczak & Francesc Baixauli, 2024. "Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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