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Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Author

Listed:
  • Yuan Yang

    (Chinese Academy of Sciences
    Third Military Medical University (Army Medical University)
    University of Chinese Academy of Sciences)

  • Ruizeng Luo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Shengyu Chao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jiangtao Xue

    (Beijing Institute of Technology)

  • Dongjie Jiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yun Hao Feng

    (Beijing University of Chemical Technology)

  • Xin Dong Guo

    (Beijing University of Chemical Technology)

  • Dan Luo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Guangxi University)

  • Jiaping Zhang

    (Third Military Medical University (Army Medical University))

  • Zhou Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Guangxi University
    Chinese Academy of Sciences)

  • Zhong Lin Wang

    (Chinese Academy of Sciences
    Georgia Institute of Technology)

Abstract

Epidermal growth factor is an excellent drug for promoting wound healing; however, its conventional administration strategies are associated with pharmacodynamic challenges, such as low transdermal permeability, reduction, and receptor desensitization. Here, we develop a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS) by integrating a sliding free-standing triboelectric nanogenerator with a microneedle patch to achieve improved epidermal growth factor pharmacodynamics. We show that the mn-STESS facilitates drug penetration and utilization by using microneedles to pierce the stratum corneum. More importantly, we find that it converts the mechanical energy of finger sliding into electricity and mediates transcutaneous electrical stimulation through microneedles. We demonstrate that the electrical stimulation applied by mn-STESS acts as an “adjuvant” that suppresses the reduction of epidermal growth factor by glutathione and upregulates its receptor expression in keratinocyte cells, successfully compensating for receptor desensitization. Collectively, this work highlights the promise of self-powered electrical adjuvants in improving drug pharmacodynamics, creating combinatorial therapeutic strategies for traditional drugs.

Suggested Citation

  • Yuan Yang & Ruizeng Luo & Shengyu Chao & Jiangtao Xue & Dongjie Jiang & Yun Hao Feng & Xin Dong Guo & Dan Luo & Jiaping Zhang & Zhou Li & Zhong Lin Wang, 2022. "Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34716-5
    DOI: 10.1038/s41467-022-34716-5
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    References listed on IDEAS

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