IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-023-44510-6.html
   My bibliography  Save this article

A self-powered intracardiac pacemaker in swine model

Author

Listed:
  • Zhuo Liu

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beihang University)

  • Yiran Hu

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    Beijing Tiantan Hospital, Capital Medical University)

  • Xuecheng Qu

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ying Liu

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Sijing Cheng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhengmin Zhang

    (Hangzhou Dianzi University)

  • Yizhu Shan

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences)

  • Ruizeng Luo

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences)

  • Sixian Weng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Hui Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Hongxia Niu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Min Gu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yan Yao

    (Capital Medical University)

  • Bojing Shi

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beihang University)

  • Ningning Wang

    (Hangzhou Dianzi University)

  • Wei Hua

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhou Li

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhong Lin Wang

    (Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Georgia Institute of Technology)

Abstract

Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction for the treatment of arrhythmia in large animal models. We show that the capsule-shaped device (1.75 g, 1.52 cc) can be integrated with a delivery catheter for implanting in the right ventricle of a swine through the intravenous route, which effectively converts cardiac motion energy to electricity and maintains endocardial pacing function during the three-week follow-up period. We measure in vivo open circuit voltage and short circuit current of the self-powered intracardiac pacemaker of about 6.0 V and 0.2 μA, respectively. This approach exhibits up-to-date progress in self-powered medical devices and it may overcome the inherent energy shortcomings of implantable pacemakers and other bioelectronic devices for therapy and sensing.

Suggested Citation

  • Zhuo Liu & Yiran Hu & Xuecheng Qu & Ying Liu & Sijing Cheng & Zhengmin Zhang & Yizhu Shan & Ruizeng Luo & Sixian Weng & Hui Li & Hongxia Niu & Min Gu & Yan Yao & Bojing Shi & Ningning Wang & Wei Hua &, 2024. "A self-powered intracardiac pacemaker in swine model," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44510-6
    DOI: 10.1038/s41467-023-44510-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-44510-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-44510-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Guang Yao & Lei Kang & Jun Li & Yin Long & Hao Wei & Carolina A. Ferreira & Justin J. Jeffery & Yuan Lin & Weibo Cai & Xudong Wang, 2018. "Effective weight control via an implanted self-powered vagus nerve stimulation device," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Han Ouyang & Zhuo Liu & Ning Li & Bojing Shi & Yang Zou & Feng Xie & Ye Ma & Zhe Li & Hu Li & Qiang Zheng & Xuecheng Qu & Yubo Fan & Zhong Lin Wang & Hao Zhang & Zhou Li, 2019. "Symbiotic cardiac pacemaker," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    3. Hanjun Ryu & Hyun-moon Park & Moo-Kang Kim & Bosung Kim & Hyoun Seok Myoung & Tae Yun Kim & Hong-Joon Yoon & Sung Soo Kwak & Jihye Kim & Tae Ho Hwang & Eue-Keun Choi & Sang-Woo Kim, 2021. "Self-rechargeable cardiac pacemaker system with triboelectric nanogenerators," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Zhouquan Sun & Yuefan Jin & Jiabei Luo & Linpeng Li & Yue Ding & Yu Luo & Yan Qi & Yaogang Li & Qinghong Zhang & Kerui Li & Haibo Shi & Shankai Yin & Hongzhi Wang & Hui Wang & Chengyi Hou, 2024. "A bioabsorbable mechanoelectric fiber as electrical stimulation suture," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Renjie Qiu & Xingying Zhang & Chen Song & Kaige Xu & Huijia Nong & Yi Li & Xianglong Xing & Kibret Mequanint & Qian Liu & Quan Yuan & Xiaomin Sun & Malcolm Xing & Leyu Wang, 2024. "E-cardiac patch to sense and repair infarcted myocardium," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Caixia Li & Yongsheng Zhu & Fengxin Sun & Changjun Jia & Tianming Zhao & Yupeng Mao & Haidong Yang, 2022. "Research Progress on Triboelectric Nanogenerator for Sports Applications," Energies, MDPI, vol. 15(16), pages 1-15, August.
    4. Shuo Li & Yong Zhang & Xiaoping Liang & Haomin Wang & Haojie Lu & Mengjia Zhu & Huimin Wang & Mingchao Zhang & Xinping Qiu & Yafeng Song & Yingying Zhang, 2022. "Humidity-sensitive chemoelectric flexible sensors based on metal-air redox reaction for health management," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Fei Jin & Tong Li & Zhidong Wei & Ruiying Xiong & Lili Qian & Juan Ma & Tao Yuan & Qi Wu & Chengteng Lai & Xiying Ma & Fuyi Wang & Ying Zhao & Fengyu Sun & Ting Wang & Zhang-Qi Feng, 2022. "Biofeedback electrostimulation for bionic and long-lasting neural modulation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Wang, Wei & Zhang, Ying & Wei, Zon-Han & Cao, Junyi, 2022. "Design and numerical investigation of an ultra-wide bandwidth rolling magnet bistable electromagnetic harvester," Energy, Elsevier, vol. 261(PB).
    7. Shanzhi Lyu & Yonglin He & Xinglei Tao & Yuge Yao & Xiangyi Huang & Yingchao Ma & Zhimin Peng & Yanjun Ding & Yapei Wang, 2022. "Subcutaneous power supply by NIR-II light," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    8. Xinjian Xie & Zhonggang Xu & Xin Yu & Hong Jiang & Hongjiao Li & Wenqian Feng, 2023. "Liquid-in-liquid printing of 3D and mechanically tunable conductive hydrogels," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    9. Yuan Yang & Ruizeng Luo & Shengyu Chao & Jiangtao Xue & Dongjie Jiang & Yun Hao Feng & Xin Dong Guo & Dan Luo & Jiaping Zhang & Zhou Li & Zhong Lin Wang, 2022. "Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44510-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.