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Symbiotic cardiac pacemaker

Author

Listed:
  • Han Ouyang

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences)

  • Zhuo Liu

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University)

  • Ning Li

    (Institute of Cardiothoracic Surgery at Changhai Hospital, Second Military Medical University)

  • Bojing Shi

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University)

  • Yang Zou

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences)

  • Feng Xie

    (Institute of Cardiothoracic Surgery at Changhai Hospital, Second Military Medical University)

  • Ye Ma

    (Institute of Cardiothoracic Surgery at Changhai Hospital, Second Military Medical University)

  • Zhe Li

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences)

  • Hu Li

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University)

  • Qiang Zheng

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences)

  • Xuecheng Qu

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences)

  • Yubo Fan

    (Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University)

  • Zhong Lin Wang

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences
    School of Materials Science and Engineering, Georgia Institute of Technology)

  • Hao Zhang

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    Institute of Cardiothoracic Surgery at Changhai Hospital, Second Military Medical University)

  • Zhou Li

    (CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
    School of Nanoscience and Technology, University of Chinese Academy of Sciences)

Abstract

Self-powered implantable medical electronic devices that harvest biomechanical energy from cardiac motion, respiratory movement and blood flow are part of a paradigm shift that is on the horizon. Here, we demonstrate a fully implanted symbiotic pacemaker based on an implantable triboelectric nanogenerator, which achieves energy harvesting and storage as well as cardiac pacing on a large-animal scale. The symbiotic pacemaker successfully corrects sinus arrhythmia and prevents deterioration. The open circuit voltage of an implantable triboelectric nanogenerator reaches up to 65.2 V. The energy harvested from each cardiac motion cycle is 0.495 μJ, which is higher than the required endocardial pacing threshold energy (0.377 μJ). Implantable triboelectric nanogenerators for implantable medical devices offer advantages of excellent output performance, high power density, and good durability, and are expected to find application in fields of treatment and diagnosis as in vivo symbiotic bioelectronics.

Suggested Citation

  • Han Ouyang & Zhuo Liu & Ning Li & Bojing Shi & Yang Zou & Feng Xie & Ye Ma & Zhe Li & Hu Li & Qiang Zheng & Xuecheng Qu & Yubo Fan & Zhong Lin Wang & Hao Zhang & Zhou Li, 2019. "Symbiotic cardiac pacemaker," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09851-1
    DOI: 10.1038/s41467-019-09851-1
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    Cited by:

    1. Caixia Li & Yongsheng Zhu & Fengxin Sun & Changjun Jia & Tianming Zhao & Yupeng Mao & Haidong Yang, 2022. "Research Progress on Triboelectric Nanogenerator for Sports Applications," Energies, MDPI, vol. 15(16), pages 1-15, August.
    2. Xinjian Xie & Zhonggang Xu & Xin Yu & Hong Jiang & Hongjiao Li & Wenqian Feng, 2023. "Liquid-in-liquid printing of 3D and mechanically tunable conductive hydrogels," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Zhuo Liu & Yiran Hu & Xuecheng Qu & Ying Liu & Sijing Cheng & Zhengmin Zhang & Yizhu Shan & Ruizeng Luo & Sixian Weng & Hui Li & Hongxia Niu & Min Gu & Yan Yao & Bojing Shi & Ningning Wang & Wei Hua &, 2024. "A self-powered intracardiac pacemaker in swine model," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Shuo Li & Yong Zhang & Xiaoping Liang & Haomin Wang & Haojie Lu & Mengjia Zhu & Huimin Wang & Mingchao Zhang & Xinping Qiu & Yafeng Song & Yingying Zhang, 2022. "Humidity-sensitive chemoelectric flexible sensors based on metal-air redox reaction for health management," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Zhouquan Sun & Yuefan Jin & Jiabei Luo & Linpeng Li & Yue Ding & Yu Luo & Yan Qi & Yaogang Li & Qinghong Zhang & Kerui Li & Haibo Shi & Shankai Yin & Hongzhi Wang & Hui Wang & Chengyi Hou, 2024. "A bioabsorbable mechanoelectric fiber as electrical stimulation suture," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    6. Shanzhi Lyu & Yonglin He & Xinglei Tao & Yuge Yao & Xiangyi Huang & Yingchao Ma & Zhimin Peng & Yanjun Ding & Yapei Wang, 2022. "Subcutaneous power supply by NIR-II light," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    7. Yuan Yang & Ruizeng Luo & Shengyu Chao & Jiangtao Xue & Dongjie Jiang & Yun Hao Feng & Xin Dong Guo & Dan Luo & Jiaping Zhang & Zhou Li & Zhong Lin Wang, 2022. "Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    8. Renjie Qiu & Xingying Zhang & Chen Song & Kaige Xu & Huijia Nong & Yi Li & Xianglong Xing & Kibret Mequanint & Qian Liu & Quan Yuan & Xiaomin Sun & Malcolm Xing & Leyu Wang, 2024. "E-cardiac patch to sense and repair infarcted myocardium," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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