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Hyperbolic material enhanced scattering nanoscopy for label-free super-resolution imaging

Author

Listed:
  • Yeon Ui Lee

    (University of California, San Diego
    Chungbuk National University)

  • Shilong Li

    (University of California, San Diego
    Okinawa Institute of Science and Technology Graduate University)

  • G. Bimananda M. Wisna

    (University of California, San Diego)

  • Junxiang Zhao

    (University of California, San Diego)

  • Yuan Zeng

    (University of California, San Diego
    University of California, San Diego)

  • Andrea R. Tao

    (University of California, San Diego
    University of California, San Diego)

  • Zhaowei Liu

    (University of California, San Diego
    University of California, San Diego)

Abstract

Fluorescence super-resolution microscopy has, over the last two decades, been extensively developed to access deep-subwavelength nanoscales optically. Label-free super-resolution technologies however have only achieved a slight improvement compared to the diffraction limit. In this context, we demonstrate a label-free imaging method, i.e., hyperbolic material enhanced scattering (HMES) nanoscopy, which breaks the diffraction limit by tailoring the light-matter interaction between the specimens and a hyperbolic material substrate. By exciting the highly confined evanescent hyperbolic polariton modes with dark-field detection, HMES nanoscopy successfully shows a high-contrast scattering image with a spatial resolution around 80 nm. Considering the wavelength at 532 nm and detection optics with a 0.6 numerical aperture (NA) objective lens, this value represents a 5.5-fold resolution improvement beyond the diffraction limit. HMES provides capabilities for super-resolution imaging where fluorescence is not available or challenging to apply.

Suggested Citation

  • Yeon Ui Lee & Shilong Li & G. Bimananda M. Wisna & Junxiang Zhao & Yuan Zeng & Andrea R. Tao & Zhaowei Liu, 2022. "Hyperbolic material enhanced scattering nanoscopy for label-free super-resolution imaging," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34553-6
    DOI: 10.1038/s41467-022-34553-6
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    References listed on IDEAS

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    1. Marek Piliarik & Vahid Sandoghdar, 2014. "Direct optical sensing of single unlabelled proteins and super-resolution imaging of their binding sites," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    2. Kerry J. Vahala, 2003. "Optical microcavities," Nature, Nature, vol. 424(6950), pages 839-846, August.
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