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A parallel randomized controlled trial examining the effects of rhythmic sensory stimulation on fibromyalgia symptoms

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  • Thenille Braun Janzen
  • Denise Paneduro
  • Larry Picard
  • Allan Gordon
  • Lee R Bartel

Abstract

This double-blind, two-arm parallel randomized controlled trial investigated the effects of gamma-frequency rhythmic sensory stimulation on fibromyalgia. We were interested in whether rhythmic sensory stimulation would promote significant changes in fibromyalgia and associated symptoms, and whether treatment effects would differ between two distinct treatment parameters. Fifty patients with a formal diagnosis of fibromyalgia were randomly assigned to two test groups. One group received vibrotactile stimulation from a continuous sine wave single-frequency stimulation (40 Hz) for 30 minutes, five days per week, over five weeks, concomitant with usual care. The second group completed the same treatment protocol but received a different stimulation, consisting of random and intermittent complex wave gamma-range vibrotactile stimulation. Fibromyalgia symptoms, pain severity and interference, depression symptoms, quality of life and sleep quality were assessed at baseline and post-intervention. Results indicated that there were statistically significant changes from baseline to post-treatment in measures of fibromyalgia symptom severity, pain interference, depression, and sleep quality. However, treatment outcomes did not differ significantly between groups. These findings provide preliminary evidence that gamma-frequency rhythmic vibroacoustic stimulation may decrease fibromyalgia symptoms and ease associated comorbidities, opening new avenues for further investigation of the effects of rhythmic sensory stimulation on chronic pain conditions.

Suggested Citation

  • Thenille Braun Janzen & Denise Paneduro & Larry Picard & Allan Gordon & Lee R Bartel, 2019. "A parallel randomized controlled trial examining the effects of rhythmic sensory stimulation on fibromyalgia symptoms," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-19, March.
    • Handle: RePEc:plo:pone00:0212021
    DOI: 10.1371/journal.pone.0212021
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    References listed on IDEAS

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    1. Hunter F. Iaccarino & Annabelle C. Singer & Anthony J. Martorell & Andrii Rudenko & Fan Gao & Tyler Z. Gillingham & Hansruedi Mathys & Jinsoo Seo & Oleg Kritskiy & Fatema Abdurrob & Chinnakkaruppan Ad, 2016. "Gamma frequency entrainment attenuates amyloid load and modifies microglia," Nature, Nature, vol. 540(7632), pages 230-235, December.
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