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Identification of evolutionarily conserved regulators of muscle mitochondrial network organization

Author

Listed:
  • Prasanna Katti

    (National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Peter T. Ajayi

    (National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Angel Aponte

    (National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Christopher K. E. Bleck

    (National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Brian Glancy

    (National Heart, Lung, and Blood Institute, National Institutes of Health
    National Institutes of Health)

Abstract

Mitochondrial networks provide coordinated energy distribution throughout muscle cells. However, pathways specifying mitochondrial networks are incompletely understood and it is unclear how they might affect contractile fiber-type. Here, we show that natural energetic demands placed on Drosophila melanogaster muscles yield native cell-types among which contractile and mitochondrial network-types are regulated differentially. Proteomic analyses of indirect flight, jump, and leg muscles, together with muscles misexpressing known fiber-type specification factor salm, identified transcription factors H15 and cut as potential mitochondrial network regulators. We demonstrate H15 operates downstream of salm regulating flight muscle contractile and mitochondrial network-type. Conversely, H15 regulates mitochondrial network configuration but not contractile type in jump and leg muscles. Further, we find that cut regulates salm expression in flight muscles and mitochondrial network configuration in leg muscles. These data indicate cell type-specific regulation of muscle mitochondrial network organization through evolutionarily conserved transcription factors cut, salm, and H15.

Suggested Citation

  • Prasanna Katti & Peter T. Ajayi & Angel Aponte & Christopher K. E. Bleck & Brian Glancy, 2022. "Identification of evolutionarily conserved regulators of muscle mitochondrial network organization," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34445-9
    DOI: 10.1038/s41467-022-34445-9
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    References listed on IDEAS

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    1. Giulia Favaro & Vanina Romanello & Tatiana Varanita & Maria Andrea Desbats & Valeria Morbidoni & Caterina Tezze & Mattia Albiero & Marta Canato & Gaia Gherardi & Diego Stefani & Cristina Mammucari & B, 2019. "DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    2. Brian Glancy & Lisa M. Hartnell & Daniela Malide & Zu-Xi Yu & Christian A. Combs & Patricia S. Connelly & Sriram Subramaniam & Robert S. Balaban, 2015. "Mitochondrial reticulum for cellular energy distribution in muscle," Nature, Nature, vol. 523(7562), pages 617-620, July.
    3. Peter T. Ajayi & Prasanna Katti & Yingfan Zhang & T. Bradley Willingham & Ye Sun & Christopher K. E. Bleck & Brian Glancy, 2022. "Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Frank Schnorrer & Cornelia Schönbauer & Christoph C. H. Langer & Georg Dietzl & Maria Novatchkova & Katharina Schernhuber & Michaela Fellner & Anna Azaryan & Martin Radolf & Alexander Stark & Krystyna, 2010. "Systematic genetic analysis of muscle morphogenesis and function in Drosophila," Nature, Nature, vol. 464(7286), pages 287-291, March.
    5. Christopher K. E. Bleck & Yuho Kim & T. Bradley Willingham & Brian Glancy, 2018. "Subcellular connectomic analyses of energy networks in striated muscle," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
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