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Mitochondrial reticulum for cellular energy distribution in muscle

Author

Listed:
  • Brian Glancy

    (National Heart Lung and Blood Institute, National Institutes of Health)

  • Lisa M. Hartnell

    (National Cancer Institute, National Institutes of Health)

  • Daniela Malide

    (National Heart Lung and Blood Institute, National Institutes of Health)

  • Zu-Xi Yu

    (National Heart Lung and Blood Institute, National Institutes of Health)

  • Christian A. Combs

    (National Heart Lung and Blood Institute, National Institutes of Health)

  • Patricia S. Connelly

    (National Heart Lung and Blood Institute, National Institutes of Health)

  • Sriram Subramaniam

    (National Cancer Institute, National Institutes of Health)

  • Robert S. Balaban

    (National Heart Lung and Blood Institute, National Institutes of Health)

Abstract

Mitochondria are shown to form a conductive pathway throughout the cell in the form of a proton motive force, and throughout this network, mitochondrial protein localization seems to be varied, allowing optimized generation and utilization of the mitochondrial membrane potential; the rapid energy distribution network, which depends on conduction rather than diffusion, could explain how the muscle can rapidly respond to energy demands.

Suggested Citation

  • Brian Glancy & Lisa M. Hartnell & Daniela Malide & Zu-Xi Yu & Christian A. Combs & Patricia S. Connelly & Sriram Subramaniam & Robert S. Balaban, 2015. "Mitochondrial reticulum for cellular energy distribution in muscle," Nature, Nature, vol. 523(7562), pages 617-620, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7562:d:10.1038_nature14614
    DOI: 10.1038/nature14614
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    Citations

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    Cited by:

    1. Prasanna Katti & Alexander S. Hall & Hailey A. Parry & Peter T. Ajayi & Yuho Kim & T. Bradley Willingham & Christopher K. E. Bleck & Han Wen & Brian Glancy, 2022. "Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Prasanna Katti & Peter T. Ajayi & Angel Aponte & Christopher K. E. Bleck & Brian Glancy, 2022. "Identification of evolutionarily conserved regulators of muscle mitochondrial network organization," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Lance T. Denes & Chase P. Kelley & Eric T. Wang, 2021. "Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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