IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30401-9.html
   My bibliography  Save this article

Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms

Author

Listed:
  • Peter T. Ajayi

    (NHLBI, NIH)

  • Prasanna Katti

    (NHLBI, NIH)

  • Yingfan Zhang

    (NHLBI, NIH)

  • T. Bradley Willingham

    (NHLBI, NIH)

  • Ye Sun

    (NHLBI, NIH)

  • Christopher K. E. Bleck

    (NHLBI, NIH)

  • Brian Glancy

    (NHLBI, NIH
    NIAMS, NIH)

Abstract

Skeletal muscles play a central role in human movement through forces transmitted by contraction of the sarcomere. We recently showed that mammalian sarcomeres are connected through frequent branches forming a singular, mesh-like myofibrillar matrix. However, the extent to which myofibrillar connectivity is evolutionarily conserved as well as mechanisms which regulate the specific architecture of sarcomere branching remain unclear. Here, we demonstrate the presence of a myofibrillar matrix in the tubular, but not indirect flight (IF) muscles within Drosophila melanogaster. Moreover, we find that loss of transcription factor H15 increases sarcomere branching frequency in the tubular jump muscles, and we show that sarcomere branching can be turned on in IF muscles by salm-mediated conversion to tubular muscles. Finally, we demonstrate that neurochondrin misexpression results in myofibrillar connectivity in IF muscles without conversion to tubular muscles. These data indicate an evolutionarily conserved myofibrillar matrix regulated by both cell-type dependent and independent mechanisms.

Suggested Citation

  • Peter T. Ajayi & Prasanna Katti & Yingfan Zhang & T. Bradley Willingham & Ye Sun & Christopher K. E. Bleck & Brian Glancy, 2022. "Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30401-9
    DOI: 10.1038/s41467-022-30401-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30401-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30401-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sergey Y. Bershitsky & Andrey K. Tsaturyan & Olga N. Bershitskaya & Gregory I. Mashanov & Paul Brown & Ronald Burns & Michael A. Ferenczi, 1997. "Muscle force is generated by myosin heads stereospecifically attached to actin," Nature, Nature, vol. 388(6638), pages 186-190, July.
    2. Jerome Avellaneda & Clement Rodier & Fabrice Daian & Nicolas Brouilly & Thomas Rival & Nuno Miguel Luis & Frank Schnorrer, 2021. "Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Frank Schnorrer & Cornelia Schönbauer & Christoph C. H. Langer & Georg Dietzl & Maria Novatchkova & Katharina Schernhuber & Michaela Fellner & Anna Azaryan & Martin Radolf & Alexander Stark & Krystyna, 2010. "Systematic genetic analysis of muscle morphogenesis and function in Drosophila," Nature, Nature, vol. 464(7286), pages 287-291, March.
    4. Kevin Y. Lee & Manvendra K. Singh & Siegfried Ussar & Petra Wetzel & Michael F. Hirshman & Laurie J. Goodyear & Andreas Kispert & C. Ronald Kahn, 2015. "Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism," Nature Communications, Nature, vol. 6(1), pages 1-12, November.
    5. Christopher K. E. Bleck & Yuho Kim & T. Bradley Willingham & Brian Glancy, 2018. "Subcellular connectomic analyses of energy networks in striated muscle," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Prasanna Katti & Alexander S. Hall & Hailey A. Parry & Peter T. Ajayi & Yuho Kim & T. Bradley Willingham & Christopher K. E. Bleck & Han Wen & Brian Glancy, 2022. "Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Prasanna Katti & Peter T. Ajayi & Angel Aponte & Christopher K. E. Bleck & Brian Glancy, 2022. "Identification of evolutionarily conserved regulators of muscle mitochondrial network organization," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Prasanna Katti & Alexander S. Hall & Hailey A. Parry & Peter T. Ajayi & Yuho Kim & T. Bradley Willingham & Christopher K. E. Bleck & Han Wen & Brian Glancy, 2022. "Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Gabriela Poliacikova & Marine Barthez & Thomas Rival & Aïcha Aouane & Nuno Miguel Luis & Fabrice Richard & Fabrice Daian & Nicolas Brouilly & Frank Schnorrer & Corinne Maurel-Zaffran & Yacine Graba & , 2023. "M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Prasanna Katti & Peter T. Ajayi & Angel Aponte & Christopher K. E. Bleck & Brian Glancy, 2022. "Identification of evolutionarily conserved regulators of muscle mitochondrial network organization," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Robert Stojnic & Audrey Qiuyan Fu & Boris Adryan, 2012. "A Graphical Modelling Approach to the Dissection of Highly Correlated Transcription Factor Binding Site Profiles," PLOS Computational Biology, Public Library of Science, vol. 8(11), pages 1-13, November.
    5. Oksana Netschitailo & Yidong Wang & Anna Wagner & Vivien Sommer & Eveline C. Verhulst & Martin Beye, 2023. "The function and evolution of a genetic switch controlling sexually dimorphic eye differentiation in honeybees," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Christopher Livelo & Yiming Guo & Farah Abou Daya & Vasanthi Rajasekaran & Shweta Varshney & Hiep D. Le & Stephen Barnes & Satchidananda Panda & Girish C. Melkani, 2023. "Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30401-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.