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Systematic genetic analysis of muscle morphogenesis and function in Drosophila

Author

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  • Frank Schnorrer

    (Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Cornelia Schönbauer

    (Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany)

  • Christoph C. H. Langer

    (Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany)

  • Georg Dietzl

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Maria Novatchkova

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Katharina Schernhuber

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Michaela Fellner

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Anna Azaryan

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Martin Radolf

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Alexander Stark

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Krystyna Keleman

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

  • Barry J. Dickson

    (Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

Abstract

Muscle genes catalogued in Drosophila A genome-wide RNAi screen has been used to define the genetic basis for the formation and function of Drosophila muscle. A total of 2,785 genes were recognized as having a role in muscle, many of then assigned to specific functions in the organization of muscles, myofibrils or sarcomeres. Many of these genes are phylogenetically conserved, and the list of conserved and functionally validated muscle genes includes a strong enrichment for genes implicated in mammalian sarcomere organization and human muscle diseases.

Suggested Citation

  • Frank Schnorrer & Cornelia Schönbauer & Christoph C. H. Langer & Georg Dietzl & Maria Novatchkova & Katharina Schernhuber & Michaela Fellner & Anna Azaryan & Martin Radolf & Alexander Stark & Krystyna, 2010. "Systematic genetic analysis of muscle morphogenesis and function in Drosophila," Nature, Nature, vol. 464(7286), pages 287-291, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7286:d:10.1038_nature08799
    DOI: 10.1038/nature08799
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    Citations

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    Cited by:

    1. Robert Stojnic & Audrey Qiuyan Fu & Boris Adryan, 2012. "A Graphical Modelling Approach to the Dissection of Highly Correlated Transcription Factor Binding Site Profiles," PLOS Computational Biology, Public Library of Science, vol. 8(11), pages 1-13, November.
    2. Peter T. Ajayi & Prasanna Katti & Yingfan Zhang & T. Bradley Willingham & Ye Sun & Christopher K. E. Bleck & Brian Glancy, 2022. "Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Oksana Netschitailo & Yidong Wang & Anna Wagner & Vivien Sommer & Eveline C. Verhulst & Martin Beye, 2023. "The function and evolution of a genetic switch controlling sexually dimorphic eye differentiation in honeybees," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Prasanna Katti & Peter T. Ajayi & Angel Aponte & Christopher K. E. Bleck & Brian Glancy, 2022. "Identification of evolutionarily conserved regulators of muscle mitochondrial network organization," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Christopher Livelo & Yiming Guo & Farah Abou Daya & Vasanthi Rajasekaran & Shweta Varshney & Hiep D. Le & Stephen Barnes & Satchidananda Panda & Girish C. Melkani, 2023. "Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Gabriela Poliacikova & Marine Barthez & Thomas Rival & Aïcha Aouane & Nuno Miguel Luis & Fabrice Richard & Fabrice Daian & Nicolas Brouilly & Frank Schnorrer & Corinne Maurel-Zaffran & Yacine Graba & , 2023. "M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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