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Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distribution of activity

Author

Listed:
  • Teagan E. Bate

    (Worcester Polytechnic Institute)

  • Megan E. Varney

    (New York University)

  • Ezra H. Taylor

    (Worcester Polytechnic Institute)

  • Joshua H. Dickie

    (Worcester Polytechnic Institute)

  • Chih-Che Chueh

    (National Cheng Kung University)

  • Michael M. Norton

    (Rochester Institute of Technology)

  • Kun-Ta Wu

    (Worcester Polytechnic Institute
    Worcester Polytechnic Institute
    Brandeis University)

Abstract

Active fluids have applications in micromixing, but little is known about the mixing kinematics of systems with spatiotemporally-varying activity. To investigate, UV-activated caged ATP is used to activate controlled regions of microtubule-kinesin active fluid and the mixing process is observed with fluorescent tracers and molecular dyes. At low Péclet numbers (diffusive transport), the active-inactive interface progresses toward the inactive area in a diffusion-like manner that is described by a simple model combining diffusion with Michaelis-Menten kinetics. At high Péclet numbers (convective transport), the active-inactive interface progresses in a superdiffusion-like manner that is qualitatively captured by an active-fluid hydrodynamic model coupled to ATP transport. Results show that active fluid mixing involves complex coupling between distribution of active stress and active transport of ATP and reduces mixing time for suspended components with decreased impact of initial component distribution. This work will inform application of active fluids to promote micromixing in microfluidic devices.

Suggested Citation

  • Teagan E. Bate & Megan E. Varney & Ezra H. Taylor & Joshua H. Dickie & Chih-Che Chueh & Michael M. Norton & Kun-Ta Wu, 2022. "Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distribution of activity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34396-1
    DOI: 10.1038/s41467-022-34396-1
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    References listed on IDEAS

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    4. Mark J. Schnitzer & Steven M. Block, 1997. "Kinesin hydrolyses one ATP per 8-nm step," Nature, Nature, vol. 388(6640), pages 386-390, July.
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