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Self-organization of microtubules and motors

Author

Listed:
  • F. J. Ndlec

    (Princeton Unviersity
    Laboratoire de Physico-Chimie Thorique, Ecole Suprieure de Physique et Chimie Industrielles)

  • T. Surrey

    (Princeton Unviersity)

  • A. C. Maggs

    (Laboratoire de Physico-Chimie Thorique, Ecole Suprieure de Physique et Chimie Industrielles)

  • S. Leibler

    (Princeton Unviersity)

Abstract

Cellular structures are established and maintained through a dynamic interplay between assembly and regulatory processes. Self-organization of molecular components provides a variety of possible spatial structures: the regulatory machinery chooses the most appropriate to express a given cellular function1. Here we study the extent and the characteristics of self-organization using microtubules and molecular motors2 as a model system. These components are known to participate in the formation of many cellular structures, such as the dynamic asters found in mitotic and meiotic spindles3,4. Purified motors and microtubules have previously been observed to form asters in vitro5. We have reproduced this result with a simple system consisting solely of multi-headed constructs of the motor protein kinesin6 and stabilized microtubules. We show that dynamic asters can also be obtained from a homogeneous solution of tubulin and motors. By varying the relative concentrations of the components, we obtain a variety of self-organized structures. Further, by studying this process in a constrained geometry of micro-fabricated glass chambers7, we demonstrate that the same final structure can be reached through different assembly ‘pathways’.

Suggested Citation

  • F. J. Ndlec & T. Surrey & A. C. Maggs & S. Leibler, 1997. "Self-organization of microtubules and motors," Nature, Nature, vol. 389(6648), pages 305-308, September.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6648:d:10.1038_38532
    DOI: 10.1038/38532
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    Cited by:

    1. Teagan E. Bate & Megan E. Varney & Ezra H. Taylor & Joshua H. Dickie & Chih-Che Chueh & Michael M. Norton & Kun-Ta Wu, 2022. "Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distribution of activity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Wei Ming Lim & Wei-Xiang Chew & Arianna Esposito Verza & Marion Pesenti & Andrea Musacchio & Thomas Surrey, 2024. "Regulation of minimal spindle midzone organization by mitotic kinases," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Frolov, Nikita & Bijnens, Bram & Ruiz-Reynés, Daniel & Gelens, Lendert, 2024. "Dynein-driven self-organization of microtubules: An entropy- and network-based analysis," Chaos, Solitons & Fractals, Elsevier, vol. 184(C).

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