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N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection

Author

Listed:
  • Tianye Zhang

    (Ningbo University)

  • Chaonan Shi

    (Henan Agricultural University)

  • Haichao Hu

    (Ningbo University)

  • Zhuo Zhang

    (Hunan Academy of Agricultural Sciences)

  • Ziqiong Wang

    (Ningbo University)

  • Zhiqing Chen

    (Ningbo University)

  • Huimin Feng

    (Ningbo University)

  • Peng Liu

    (Ningbo University)

  • Jun Guo

    (Ningbo University)

  • Qisen Lu

    (Ningbo University)

  • Kaili Zhong

    (Ningbo University)

  • ZhiHui Chen

    (University of Dundee, School of Life Sciences)

  • Jiaqian Liu

    (Ningbo University)

  • Jiancheng Yu

    (Ningbo University)

  • Jianping Chen

    (Ningbo University)

  • Feng Chen

    (Henan Agricultural University)

  • Jian Yang

    (Ningbo University)

Abstract

Molecular manipulation of susceptibility (S) genes that are antipodes to resistance (R) genes has been adopted as an alternative strategy for controlling crop diseases. Here, we show the S gene encoding Triticum aestivum m6A methyltransferase B (TaMTB) is identified by a genome-wide association study and subsequently shown to be a positive regulator for wheat yellow mosaic virus (WYMV) infection. TaMTB is localized in the nucleus, is translocated into the cytoplasmic aggregates by binding to WYMV NIb to upregulate the m6A level of WYMV RNA1 and stabilize the viral RNA, thus promoting viral infection. A natural mutant allele TaMTB-SNP176C is found to confer an enhanced susceptibility to WYMV infection through genetic variation analysis on 243 wheat varieties. Our discovery highlights this allele can be a useful target for the molecular wheat breeding in the future.

Suggested Citation

  • Tianye Zhang & Chaonan Shi & Haichao Hu & Zhuo Zhang & Ziqiong Wang & Zhiqing Chen & Huimin Feng & Peng Liu & Jun Guo & Qisen Lu & Kaili Zhong & ZhiHui Chen & Jiaqian Liu & Jiancheng Yu & Jianping Che, 2022. "N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34362-x
    DOI: 10.1038/s41467-022-34362-x
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    References listed on IDEAS

    as
    1. Xiang Wang & Jing Feng & Yuan Xue & Zeyuan Guan & Delin Zhang & Zhu Liu & Zhou Gong & Qiang Wang & Jinbo Huang & Chun Tang & Tingting Zou & Ping Yin, 2016. "Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex," Nature, Nature, vol. 534(7608), pages 575-578, June.
    2. Shengnan Li & Dexing Lin & Yunwei Zhang & Min Deng & Yongxing Chen & Bin Lv & Boshu Li & Yuan Lei & Yanpeng Wang & Long Zhao & Yueting Liang & Jinxing Liu & Kunling Chen & Zhiyong Liu & Jun Xiao & Jin, 2022. "Genome-edited powdery mildew resistance in wheat without growth penalties," Nature, Nature, vol. 602(7897), pages 455-460, February.
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