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An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation

Author

Listed:
  • Masaki Takasugi

    (Graduate School of Medicine)

  • Yoshiki Nonaka

    (Graduate School of Medicine)

  • Kazuaki Takemura

    (Graduate School of Medicine)

  • Yuya Yoshida

    (Graduate School of Medicine)

  • Frank Stein

    (EMBL Heidelberg)

  • Jennifer J. Schwarz

    (EMBL Heidelberg)

  • Jun Adachi

    (Health and Nutrition)

  • Junko Satoh

    (Kyoto University)

  • Shinji Ito

    (Kyoto University)

  • Gregory Tombline

    (University of Rochester)

  • Seyed Ali Biashad

    (University of Rochester)

  • Andrei Seluanov

    (University of Rochester)

  • Vera Gorbunova

    (University of Rochester)

  • Naoko Ohtani

    (Graduate School of Medicine)

Abstract

To what extent and how post-transcriptional dysregulation affects aging proteome remains unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility protein-enriched fractions (LSF) of major tissues collected from mice of 6, 15, 24, and 30 months of age. Low-solubility proteins are preferentially affected by age and the analysis of LSF doubles the number of proteins identified to be differentially expressed with age. Simultaneous analysis of proteome and transcriptome using the same tissue homogenates reveals the features of age-related post-transcriptional dysregulation. Post-transcriptional dysregulation becomes evident especially after 24 months of age and age-related post-transcriptional dysregulation leads to accumulation of core matrisome proteins and reduction of mitochondrial membrane proteins in multiple tissues. Based on our in-depth proteomic data and sample-matched transcriptome data of adult, middle-aged, old, and geriatric mice, we construct the Mouse aging proteomic atlas ( https://aging-proteomics.info/ ), which provides a thorough and integrative view of age-related gene expression changes.

Suggested Citation

  • Masaki Takasugi & Yoshiki Nonaka & Kazuaki Takemura & Yuya Yoshida & Frank Stein & Jennifer J. Schwarz & Jun Adachi & Junko Satoh & Shinji Ito & Gregory Tombline & Seyed Ali Biashad & Andrei Seluanov , 2024. "An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52845-x
    DOI: 10.1038/s41467-024-52845-x
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    References listed on IDEAS

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    1. Erminia Donnarumma & Michael Kohlhaas & Elodie Vimont & Etienne Kornobis & Thibault Chaze & Quentin Giai Gianetto & Mariette Matondo & Maryse Moya-Nilges & Christoph Maack & Timothy Wai, 2022. "Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
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