Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity
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DOI: 10.1038/s41467-022-34055-5
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- Tilman Flock & Charles N. J. Ravarani & Dawei Sun & A. J. Venkatakrishnan & Melis Kayikci & Christopher G. Tate & Dmitry B. Veprintsev & M. Madan Babu, 2015. "Universal allosteric mechanism for Gα activation by GPCRs," Nature, Nature, vol. 524(7564), pages 173-179, August.
- Javier García-Nafría & Rony Nehmé & Patricia C. Edwards & Christopher G. Tate, 2018. "Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go," Nature, Nature, vol. 558(7711), pages 620-623, June.
- Konrad J. Karczewski & Laurent C. Francioli & Grace Tiao & Beryl B. Cummings & Jessica Alföldi & Qingbo Wang & Ryan L. Collins & Kristen M. Laricchia & Andrea Ganna & Daniel P. Birnbaum & Laura D. Gau, 2020. "The mutational constraint spectrum quantified from variation in 141,456 humans," Nature, Nature, vol. 581(7809), pages 434-443, May.
- Hideaki E. Kato & Yan Zhang & Hongli Hu & Carl-Mikael Suomivuori & Francois Marie Ngako Kadji & Junken Aoki & Kaavya Krishna Kumar & Rasmus Fonseca & Daniel Hilger & Weijiao Huang & Naomi R. Latorraca, 2019. "Conformational transitions of a neurotensin receptor 1–Gi1 complex," Nature, Nature, vol. 572(7767), pages 80-85, August.
- Christopher J. Draper-Joyce & Maryam Khoshouei & David M. Thal & Yi-Lynn Liang & Anh T. N. Nguyen & Sebastian G. B. Furness & Hariprasad Venugopal & Jo-Anne Baltos & Jürgen M. Plitzko & Radostin Danev, 2018. "Structure of the adenosine-bound human adenosine A1 receptor–Gi complex," Nature, Nature, vol. 558(7711), pages 559-563, June.
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- Andrew J. Y. Jones & Thomas H. Harman & Matthew Harris & Oliver E. Lewis & Graham Ladds & Daniel Nietlispach, 2024. "Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Kazem Asadollahi & Sunnia Rajput & Lazarus Andrew Zhang & Ching-Seng Ang & Shuai Nie & Nicholas A. Williamson & Michael D. W. Griffin & Ross A. D. Bathgate & Daniel J. Scott & Thomas R. Weikl & Guy N., 2023. "Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
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