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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner

Author

Listed:
  • Tatiana Dandolini Saccon

    (Institute of Biology, University of Campinas)

  • Felippe Mousovich-Neto

    (Institute of Biology, University of Campinas)

  • Raissa Guimarães Ludwig

    (Institute of Biology, University of Campinas)

  • Victor Corasolla Carregari

    (Institute of Biology, University of Campinas)

  • Ana Beatriz Anjos Souza

    (University of São Paulo)

  • Amanda Stephane Cruz Passos

    (University of São Paulo
    Center for Research in Inflammatory Diseases)

  • Matheus Cavalheiro Martini

    (University of Campinas)

  • Priscilla Paschoal Barbosa

    (University of Campinas)

  • Gabriela Fabiano Souza

    (University of Campinas)

  • Stéfanie Primon Muraro

    (University of Campinas)

  • Julia Forato

    (University of Campinas)

  • Mariene Ribeiro Amorim

    (University of Campinas)

  • Rafael Elias Marques

    (Brazilian Center for Research in Energy and Materials (CNPEM))

  • Flavio Protasio Veras

    (University of São Paulo
    Center for Research in Inflammatory Diseases
    University of São Paulo)

  • Ester Barreto

    (University of São Paulo
    Center for Research in Inflammatory Diseases)

  • Tiago Tomazini Gonçalves

    (Center for Research in Inflammatory Diseases
    Faculty of Medical Sciences, University of Campinas)

  • Isadora Marques Paiva

    (University of São Paulo
    Center for Research in Inflammatory Diseases)

  • Narayana P. B. Fazolini

    (Institute of Biology, University of Campinas)

  • Carolina Mie Kawagosi Onodera

    (University of Campinas)

  • Ronaldo Bragança Martins Junior

    (University of São Paulo)

  • Paulo Henrique Cavalcanti Araújo

    (University of São Paulo)

  • Sabrina Setembre Batah

    (University of São Paulo)

  • Rosa Maria Mendes Viana

    (University of São Paulo)

  • Danilo Machado Melo

    (University of São Paulo)

  • Alexandre Todorovic Fabro

    (University of São Paulo)

  • Eurico Arruda

    (University of São Paulo)

  • Fernando Cunha

    (University of São Paulo
    Center for Research in Inflammatory Diseases)

  • Thiago Mattar Cunha

    (University of São Paulo
    Center for Research in Inflammatory Diseases)

  • Marco Antônio M. Pretti

    (Brazilian National Cancer Institute (INCA))

  • Bradley Joseph Smith

    (Institute of Biology, University of Campinas)

  • Henrique Marques-Souza

    (Institute of Biology, University of Campinas)

  • Thiago L. Knittel

    (Institute of Biology, University of Campinas)

  • Gabriel Palermo Ruiz

    (Institute of Biology, University of Campinas)

  • Gerson S. Profeta

    (Institute of Biology, University of Campinas)

  • Tereza Cristina Minto Fontes-Cal

    (Institute of Biology, University of Campinas
    University of Campinas)

  • Mariana Boroni

    (Brazilian National Cancer Institute (INCA)
    University of Campinas)

  • Marco Aurélio Ramirez Vinolo

    (University of Campinas
    University of Campinas
    University of Campinas)

  • Alessandro S. Farias

    (University of Campinas
    University of Campinas
    University of Campinas)

  • Pedro Manoel M. Moraes-Vieira

    (University of Campinas
    University of Campinas
    University of Campinas)

  • Joyce Maria Annichino Bizzacchi

    (University of Campinas)

  • Tambet Teesalu

    (University of Tartu)

  • Felipe David Mendonça Chaim

    (University of Campinas)

  • Everton Cazzo

    (University of Campinas)

  • Elinton Adami Chaim

    (University of Campinas)

  • José Luiz Proença-Módena

    (University of Campinas
    University of Campinas)

  • Daniel Martins-de-Souza

    (Institute of Biology, University of Campinas
    University of Campinas
    University of Campinas
    D’Or Institute for Research and Education (IDOR))

  • Mariana Kiomy Osako

    (University of São Paulo)

  • Luiz Osório Leiria

    (University of São Paulo
    Center for Research in Inflammatory Diseases)

  • Marcelo A. Mori

    (Institute of Biology, University of Campinas
    University of Campinas
    University of Campinas
    Conselho Nacional de Desenvolvimento Científico e Tecnológico)

Abstract

Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells and the viral lineage. Visceral fat cells express more ACE2 and are more susceptible to SARS-CoV-2 infection than their subcutaneous counterparts. SARS-CoV-2 infection leads to inhibition of lipolysis in subcutaneous fat cells, while in visceral fat cells, it results in higher expression of pro-inflammatory cytokines. Viral load and cellular response are attenuated when visceral fat cells are infected with the SARS-CoV-2 gamma variant. A similar degree of cell death occurs 4-days after SARS-CoV-2 infection, regardless of the cell origin or viral lineage. Hence, SARS-CoV-2 infects human fat cells, replicating and altering cell function and viability in a depot- and viral lineage-dependent fashion.

Suggested Citation

  • Tatiana Dandolini Saccon & Felippe Mousovich-Neto & Raissa Guimarães Ludwig & Victor Corasolla Carregari & Ana Beatriz Anjos Souza & Amanda Stephane Cruz Passos & Matheus Cavalheiro Martini & Priscill, 2022. "SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33218-8
    DOI: 10.1038/s41467-022-33218-8
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    1. Wenfei Sun & Hua Dong & Miroslav Balaz & Michal Slyper & Eugene Drokhlyansky & Georgia Colleluori & Antonio Giordano & Zuzana Kovanicova & Patrik Stefanicka & Lucia Balazova & Lianggong Ding & Anna So, 2020. "snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis," Nature, Nature, vol. 587(7832), pages 98-102, November.
    2. Yingyao Zhou & Bin Zhou & Lars Pache & Max Chang & Alireza Hadj Khodabakhshi & Olga Tanaseichuk & Christopher Benner & Sumit K. Chanda, 2019. "Metascape provides a biologist-oriented resource for the analysis of systems-level datasets," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
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    1. Kaisa Hofwimmer & Joyce de Paula Souza & Narmadha Subramanian & Milica Vujičić & Leila Rachid & Hélène Méreau & Cheng Zhao & Erez Dror & Emelie Barreby & Niklas K. Björkström & Ingrid Wernstedt Aste, 2024. "IL-1β promotes adipogenesis by directly targeting adipocyte precursors," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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