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STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells

Author

Listed:
  • Ryuki Shimada

    (Kumamoto university)

  • Yuzuru Kato

    (National Institute of Genetics, Mishima)

  • Naoki Takeda

    (Kumamoto University)

  • Sayoko Fujimura

    (Kumamoto University)

  • Kei-ichiro Yasunaga

    (Kumamoto University)

  • Shingo Usuki

    (Kumamoto University)

  • Hitoshi Niwa

    (Kumamoto university)

  • Kimi Araki

    (Kumamoto University
    Kumamoto University)

  • Kei-ichiro Ishiguro

    (Kumamoto university)

Abstract

Meiosis is differently regulated in males and females. In females, germ cells initiate meiosis within a limited time period in the fetal ovary and undergo a prolonged meiotic arrest until puberty. However, how meiosis initiation is coordinated with the cell cycle to coincide with S phase remains elusive. Here, we demonstrate that STRA8 binds to RB via the LXCXE motif. Mutation of the RB-binding site of STRA8 in female mice delays meiotic entry, which consequently delays progression of meiotic prophase and leads to precocious depletion of the oocyte pool. Single-cell RNA-sequencing analysis reveals that the STRA8–RB interaction is required for S phase entry and meiotic gene activation, ensuring precise timing of meiosis initiation in oocytes. Strikingly, the results suggest STRA8 could sequester RB from E2F during pre-meiotic G1/S transition. This study highlights the gene regulatory mechanisms underlying the female-specific mode of meiotic initiation in mice.

Suggested Citation

  • Ryuki Shimada & Yuzuru Kato & Naoki Takeda & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Hitoshi Niwa & Kimi Araki & Kei-ichiro Ishiguro, 2023. "STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42259-6
    DOI: 10.1038/s41467-023-42259-6
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    1. Saori Yoshimura & Ryuki Shimada & Koji Kikuchi & Soichiro Kawagoe & Hironori Abe & Sakie Iisaka & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Naoki Tani & Takashi Ohba & Eiji Kondoh & Tomoh, 2024. "Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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