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IL-1β promotes adipogenesis by directly targeting adipocyte precursors

Author

Listed:
  • Kaisa Hofwimmer

    (Karolinska Institutet)

  • Joyce de Paula Souza

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Narmadha Subramanian

    (Karolinska Institutet)

  • Milica Vujičić

    (The Sahlgrenska Academy at University of Gothenburg)

  • Leila Rachid

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Hélène Méreau

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Cheng Zhao

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Erez Dror

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Emelie Barreby

    (Karolinska Institutet, Karolinska University Hospital)

  • Niklas K. Björkström

    (Karolinska Institutet, Karolinska University Hospital)

  • Ingrid Wernstedt Asterholm

    (The Sahlgrenska Academy at University of Gothenburg)

  • Marianne Böni-Schnetzler

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Daniel T. Meier

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Marc Y. Donath

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Jurga Laurencikiene

    (Karolinska Institutet)

Abstract

Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1) has no metabolic consequences, whereas ubiquitous lack of IL1R1 reduces body weight, WAT mass, and adipocyte formation in mice. Among all major WAT-resident cell types, progenitors express the highest IL1R1 levels. In vitro, IL-1β potently promotes adipogenesis in murine and human adipose-derived stem cells. This effect is exclusive to early-differentiation-stage cells, in which the adipogenic transcription factors C/EBPδ and C/EBPβ are rapidly upregulated by IL-1β and enriched near important adipogenic genes. The pro-adipogenic, but not pro-inflammatory effect of IL-1β is potentiated by acute treatment and blocked by chronic exposure. Thus, we propose that transient postprandial IL-1β surges regulate WAT remodeling by promoting adipogenesis, whereas chronically elevated IL-1β levels in obesity blunts this physiological function.

Suggested Citation

  • Kaisa Hofwimmer & Joyce de Paula Souza & Narmadha Subramanian & Milica Vujičić & Leila Rachid & Hélène Méreau & Cheng Zhao & Erez Dror & Emelie Barreby & Niklas K. Björkström & Ingrid Wernstedt Aste, 2024. "IL-1β promotes adipogenesis by directly targeting adipocyte precursors," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51938-x
    DOI: 10.1038/s41467-024-51938-x
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    References listed on IDEAS

    as
    1. Weiwei Liu & Hao Zhou & Han Wang & Quanri Zhang & Renliang Zhang & Belinda Willard & Caini Liu & Zizhen Kang & Xiao Li & Xiaoxia Li, 2022. "IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Tatiana Dandolini Saccon & Felippe Mousovich-Neto & Raissa Guimarães Ludwig & Victor Corasolla Carregari & Ana Beatriz Anjos Souza & Amanda Stephane Cruz Passos & Matheus Cavalheiro Martini & Priscill, 2022. "SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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