IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-51938-x.html
   My bibliography  Save this article

IL-1β promotes adipogenesis by directly targeting adipocyte precursors

Author

Listed:
  • Kaisa Hofwimmer

    (Karolinska Institutet)

  • Joyce de Paula Souza

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Narmadha Subramanian

    (Karolinska Institutet)

  • Milica Vujičić

    (The Sahlgrenska Academy at University of Gothenburg)

  • Leila Rachid

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Hélène Méreau

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Cheng Zhao

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Erez Dror

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Emelie Barreby

    (Karolinska Institutet, Karolinska University Hospital)

  • Niklas K. Björkström

    (Karolinska Institutet, Karolinska University Hospital)

  • Ingrid Wernstedt Asterholm

    (The Sahlgrenska Academy at University of Gothenburg)

  • Marianne Böni-Schnetzler

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Daniel T. Meier

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Marc Y. Donath

    (University of Basel and University Hospital Basel
    University Hospital Basel)

  • Jurga Laurencikiene

    (Karolinska Institutet)

Abstract

Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1) has no metabolic consequences, whereas ubiquitous lack of IL1R1 reduces body weight, WAT mass, and adipocyte formation in mice. Among all major WAT-resident cell types, progenitors express the highest IL1R1 levels. In vitro, IL-1β potently promotes adipogenesis in murine and human adipose-derived stem cells. This effect is exclusive to early-differentiation-stage cells, in which the adipogenic transcription factors C/EBPδ and C/EBPβ are rapidly upregulated by IL-1β and enriched near important adipogenic genes. The pro-adipogenic, but not pro-inflammatory effect of IL-1β is potentiated by acute treatment and blocked by chronic exposure. Thus, we propose that transient postprandial IL-1β surges regulate WAT remodeling by promoting adipogenesis, whereas chronically elevated IL-1β levels in obesity blunts this physiological function.

Suggested Citation

  • Kaisa Hofwimmer & Joyce de Paula Souza & Narmadha Subramanian & Milica Vujičić & Leila Rachid & Hélène Méreau & Cheng Zhao & Erez Dror & Emelie Barreby & Niklas K. Björkström & Ingrid Wernstedt Aste, 2024. "IL-1β promotes adipogenesis by directly targeting adipocyte precursors," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51938-x
    DOI: 10.1038/s41467-024-51938-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-51938-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-51938-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Weiwei Liu & Hao Zhou & Han Wang & Quanri Zhang & Renliang Zhang & Belinda Willard & Caini Liu & Zizhen Kang & Xiao Li & Xiaoxia Li, 2022. "IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Tatiana Dandolini Saccon & Felippe Mousovich-Neto & Raissa Guimarães Ludwig & Victor Corasolla Carregari & Ana Beatriz Anjos Souza & Amanda Stephane Cruz Passos & Matheus Cavalheiro Martini & Priscill, 2022. "SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51938-x. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.