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AC amplification gain in organic electrochemical transistors for impedance-based single cell sensors

Author

Listed:
  • Filippo Bonafè

    (University of Bologna)

  • Francesco Decataldo

    (University of Bologna)

  • Isabella Zironi

    (University of Bologna)

  • Daniel Remondini

    (University of Bologna)

  • Tobias Cramer

    (University of Bologna)

  • Beatrice Fraboni

    (University of Bologna)

Abstract

Research on electrolyte-gated and organic electrochemical transistor (OECT) architectures is motivated by the prospect of a highly biocompatible interface capable of amplifying bioelectronic signals at the site of detection. Despite many demonstrations in these directions, a quantitative model for OECTs as impedance biosensors is still lacking. We overcome this issue by introducing a model experiment where we simulate the detection of a single cell by the impedance sensing of a dielectric microparticle. The highly reproducible experiment allows us to study the impact of transistor geometry and operation conditions on device sensitivity. With the data we rationalize a mathematical model that provides clear guidelines for the optimization of OECTs as single cell sensors, and we verify the quantitative predictions in an in-vitro experiment. In the optimized geometry, the OECT-based impedance sensor allows to record single cell adhesion and detachment transients, showing a maximum gain of 20.2±0.9 dB with respect to a single electrode-based impedance sensor.

Suggested Citation

  • Filippo Bonafè & Francesco Decataldo & Isabella Zironi & Daniel Remondini & Tobias Cramer & Beatrice Fraboni, 2022. "AC amplification gain in organic electrochemical transistors for impedance-based single cell sensors," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33094-2
    DOI: 10.1038/s41467-022-33094-2
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    References listed on IDEAS

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    1. Dion Khodagholy & Thomas Doublet & Pascale Quilichini & Moshe Gurfinkel & Pierre Leleux & Antoine Ghestem & Esma Ismailova & Thierry Hervé & Sébastien Sanaur & Christophe Bernard & George G. Malliaras, 2013. "In vivo recordings of brain activity using organic transistors," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    2. Dion Khodagholy & Jonathan Rivnay & Michele Sessolo & Moshe Gurfinkel & Pierre Leleux & Leslie H. Jimison & Eleni Stavrinidou & Thierry Herve & Sébastien Sanaur & Róisín M. Owens & George G. Malliaras, 2013. "High transconductance organic electrochemical transistors," Nature Communications, Nature, vol. 4(1), pages 1-6, October.
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