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In vivo recordings of brain activity using organic transistors

Author

Listed:
  • Dion Khodagholy

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC)

  • Thomas Doublet

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
    Aix Marseille Université, INS
    Inserm, UMR_S 1106
    Microvitae Technologies, Pôle d’Activité Y. Morandat)

  • Pascale Quilichini

    (Aix Marseille Université, INS
    Inserm, UMR_S 1106)

  • Moshe Gurfinkel

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC)

  • Pierre Leleux

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
    Aix Marseille Université, INS
    Inserm, UMR_S 1106
    Microvitae Technologies, Pôle d’Activité Y. Morandat)

  • Antoine Ghestem

    (Aix Marseille Université, INS
    Inserm, UMR_S 1106)

  • Esma Ismailova

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC)

  • Thierry Hervé

    (Microvitae Technologies, Pôle d’Activité Y. Morandat)

  • Sébastien Sanaur

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC)

  • Christophe Bernard

    (Aix Marseille Université, INS
    Inserm, UMR_S 1106)

  • George G. Malliaras

    (Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC)

Abstract

In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.

Suggested Citation

  • Dion Khodagholy & Thomas Doublet & Pascale Quilichini & Moshe Gurfinkel & Pierre Leleux & Antoine Ghestem & Esma Ismailova & Thierry Hervé & Sébastien Sanaur & Christophe Bernard & George G. Malliaras, 2013. "In vivo recordings of brain activity using organic transistors," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2573
    DOI: 10.1038/ncomms2573
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    Cited by:

    1. Matteo Cucchi & Anton Weissbach & Lukas M. Bongartz & Richard Kantelberg & Hsin Tseng & Hans Kleemann & Karl Leo, 2022. "Thermodynamics of organic electrochemical transistors," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Eyal Stein & Oded Nahor & Mikhail Stolov & Viatcheslav Freger & Iuliana Maria Petruta & Iain McCulloch & Gitti L. Frey, 2022. "Ambipolar blend-based organic electrochemical transistors and inverters," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Lawrence Coles & Domenico Ventrella & Alejandro Carnicer-Lombarte & Alberto Elmi & Joe G. Troughton & Massimo Mariello & Salim El Hadwe & Ben J. Woodington & Maria L. Bacci & George G. Malliaras & Dam, 2024. "Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Filippo Bonafè & Francesco Decataldo & Isabella Zironi & Daniel Remondini & Tobias Cramer & Beatrice Fraboni, 2022. "AC amplification gain in organic electrochemical transistors for impedance-based single cell sensors," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. Padinhare Cholakkal Harikesh & Chi-Yuan Yang & Deyu Tu & Jennifer Y. Gerasimov & Abdul Manan Dar & Adam Armada-Moreira & Matteo Massetti & Renee Kroon & David Bliman & Roger Olsson & Eleni Stavrinidou, 2022. "Organic electrochemical neurons and synapses with ion mediated spiking," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    6. Xudong Ji & Xuanyi Lin & Jonathan Rivnay, 2023. "Organic electrochemical transistors as on-site signal amplifiers for electrochemical aptamer-based sensing," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    7. Sophie Griggs & Adam Marks & Dilara Meli & Gonzague Rebetez & Olivier Bardagot & Bryan D. Paulsen & Hu Chen & Karrie Weaver & Mohamad I. Nugraha & Emily A. Schafer & Joshua Tropp & Catherine M. Aitchi, 2022. "The effect of residual palladium on the performance of organic electrochemical transistors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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