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Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

Author

Listed:
  • Kazuya Ono

    (National Institutes of Health)

  • James Keller

    (National Institutes of Health
    Qiagen Sciences Inc.)

  • Omar López Ramírez

    (University of Chicago)

  • Antonia González Garrido

    (University of Chicago)

  • Omid A. Zobeiri

    (Department of Physiology McGill University)

  • Hui Ho Vanessa Chang

    (Department of Physiology McGill University)

  • Sarath Vijayakumar

    (University of Nebraska-Lincoln)

  • Andrianna Ayiotis

    (Johns Hopkins University School of Medicine)

  • Gregg Duester

    (Stanford Burnham Prebys Medical Discovery Institutes)

  • Charles C. Della Santina

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Sherri M. Jones

    (University of Nebraska-Lincoln)

  • Kathleen E. Cullen

    (Johns Hopkins University School of Medicine)

  • Ruth Anne Eatock

    (University of Chicago)

  • Doris K. Wu

    (National Institutes of Health)

Abstract

Each vestibular sensory epithelium in the inner ear is divided morphologically and physiologically into two zones, called the striola and extrastriola in otolith organ maculae, and the central and peripheral zones in semicircular canal cristae. We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). In Cyp26b1 conditional knockout mice, formation of striolar/central zones is compromised, such that they resemble extrastriolar/peripheral zones in multiple features. Mutants have deficient vestibular evoked potential (VsEP) responses to jerk stimuli, head tremor and deficits in balance beam tests that are consistent with abnormal vestibular input, but normal vestibulo-ocular reflexes and apparently normal motor performance during swimming. Thus, degradation of RA during embryogenesis is required for formation of highly specialized regions of the vestibular sensory epithelia with specific functions in detecting head motions.

Suggested Citation

  • Kazuya Ono & James Keller & Omar López Ramírez & Antonia González Garrido & Omid A. Zobeiri & Hui Ho Vanessa Chang & Sarath Vijayakumar & Andrianna Ayiotis & Gregg Duester & Charles C. Della Santina &, 2020. "Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13710-4
    DOI: 10.1038/s41467-019-13710-4
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    Cited by:

    1. Zhikai Liu & David G. C. Hildebrand & Joshua L. Morgan & Yizhen Jia & Nicholas Slimmon & Martha W. Bagnall, 2022. "Organization of the gravity-sensing system in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Tian Wang & Tian Yang & Amanda Kedaigle & Gabriela Pregernig & Ryan McCarthy & Ben Holmes & Xudong Wu & Lars Becker & Ning Pan & Kathy So & Leon Chen & Jun He & Ahmad Mahmoudi & Soumya Negi & Monika K, 2024. "Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Young Rae Ji & Yosuke Tona & Talah Wafa & Matthew E. Christman & Edward D. Tourney & Tao Jiang & Sho Ohta & Hui Cheng & Tracy Fitzgerald & Bernd Fritzsch & Sherri M. Jones & Kathleen E. Cullen & Doris, 2022. "Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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