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No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

Author

Listed:
  • Borja Martinez-Tellez

    (University of Granada
    Leiden University Medical Center
    University of Almería)

  • Guillermo Sanchez-Delgado

    (University of Granada
    Pennington Biomedical Research Center)

  • Francisco M. Acosta

    (University of Granada
    University of Turku
    Turku University Hospital
    University of Turku)

  • Juan M. A. Alcantara

    (University of Granada)

  • Francisco J. Amaro-Gahete

    (University of Granada
    School of Medicine, University of Granada)

  • Wendy D. Martinez-Avila

    (University of Granada)

  • Elisa Merchan-Ramirez

    (University of Granada)

  • Victoria Muñoz-Hernandez

    (University of Granada)

  • Francisco J. Osuna-Prieto

    (University of Granada
    University of Granada
    Research and Development of Functional Food Center (CIDAF))

  • Lucas Jurado-Fasoli

    (University of Granada)

  • Huiwen Xu

    (University of Granada
    University of Granada)

  • Lourdes Ortiz-Alvarez

    (University of Granada
    University of Granada)

  • María J. Arias-Tellez

    (University of Granada
    University of Chile, Independence)

  • Andrea Mendez-Gutierrez

    (University of Granada
    University of Granada
    Instituto de Investigación Biosanitaria, ibs.Granada
    CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN))

  • Idoia Labayen

    (Public University of Navarra, Campus de Arrosadía)

  • Francisco B. Ortega

    (University of Granada
    University of Jyväskylä)

  • Milena Schönke

    (Leiden University Medical Center)

  • Patrick C. N. Rensen

    (Leiden University Medical Center)

  • Concepción M. Aguilera

    (University of Granada
    Instituto de Investigación Biosanitaria, ibs.Granada
    CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN))

  • José M. Llamas-Elvira

    (Instituto de Investigación Biosanitaria, ibs.Granada
    Virgen de las Nieves University Hospital
    Biohealth Research Institute in Granada)

  • Ángel Gil

    (University of Granada
    Instituto de Investigación Biosanitaria, ibs.Granada
    CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN))

  • Jonatan R. Ruiz

    (University of Granada
    Instituto de Investigación Biosanitaria, ibs.Granada)

Abstract

Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6 ml; Δ MOD-EX: −15.5 ± 62.1 ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1 ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.

Suggested Citation

  • Borja Martinez-Tellez & Guillermo Sanchez-Delgado & Francisco M. Acosta & Juan M. A. Alcantara & Francisco J. Amaro-Gahete & Wendy D. Martinez-Avila & Elisa Merchan-Ramirez & Victoria Muñoz-Hernandez , 2022. "No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32502-x
    DOI: 10.1038/s41467-022-32502-x
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    References listed on IDEAS

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    1. Denis P. Blondin & Hans C. Tingelstad & Christophe Noll & Frédérique Frisch & Serge Phoenix & Brigitte Guérin & Éric E Turcotte & Denis Richard & François Haman & André C. Carpentier, 2017. "Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men," Nature Communications, Nature, vol. 8(1), pages 1-9, April.
    2. Wenfei Sun & Hua Dong & Miroslav Balaz & Michal Slyper & Eugene Drokhlyansky & Georgia Colleluori & Antonio Giordano & Zuzana Kovanicova & Patrik Stefanicka & Lucia Balazova & Lianggong Ding & Anna So, 2020. "snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis," Nature, Nature, vol. 587(7832), pages 98-102, November.
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