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Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

Author

Listed:
  • Denis P. Blondin

    (Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke)

  • Hans C. Tingelstad

    (Faculty of Health Sciences, University of Ottawa)

  • Christophe Noll

    (Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke)

  • Frédérique Frisch

    (Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke)

  • Serge Phoenix

    (Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke
    Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke)

  • Brigitte Guérin

    (Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke)

  • Éric E Turcotte

    (Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke)

  • Denis Richard

    (Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval)

  • François Haman

    (Faculty of Health Sciences, University of Ottawa)

  • André C. Carpentier

    (Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke)

Abstract

In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid (18FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.

Suggested Citation

  • Denis P. Blondin & Hans C. Tingelstad & Christophe Noll & Frédérique Frisch & Serge Phoenix & Brigitte Guérin & Éric E Turcotte & Denis Richard & François Haman & André C. Carpentier, 2017. "Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men," Nature Communications, Nature, vol. 8(1), pages 1-9, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14146
    DOI: 10.1038/ncomms14146
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    Cited by:

    1. Borja Martinez-Tellez & Guillermo Sanchez-Delgado & Francisco M. Acosta & Juan M. A. Alcantara & Francisco J. Amaro-Gahete & Wendy D. Martinez-Avila & Elisa Merchan-Ramirez & Victoria Muñoz-Hernandez , 2022. "No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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