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Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation

Author

Listed:
  • Shengnan Liu

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Siyi Shen

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Ying Yan

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Chao Sun

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Zhiqiang Lu

    (Fudan University
    Fudan University)

  • Hua Feng

    (Chinese Academy of Sciences)

  • Yiruo Ma

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Zhili Tang

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Jing Yu

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Yuting Wu

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Balázs Gereben

    (Institute of Experimental Medicine)

  • Petra Mohácsik

    (Institute of Experimental Medicine)

  • Csaba Fekete

    (Institute of Experimental Medicine)

  • Xiaoyun Feng

    (Shanghai Jiaotong University)

  • Feixiang Yuan

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Feifan Guo

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Cheng Hu

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Mengle Shao

    (Chinese Academy of Sciences)

  • Xin Gao

    (Fudan University
    Fudan University)

  • Lin Zhao

    (Fudan University
    Fudan University)

  • Yuying Li

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Jingjing Jiang

    (Fudan University
    Fudan University)

  • Hao Ying

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
    Innovation Center for Intervention of Chronic Disease and Promotion of Health
    Ministry of Health)

Abstract

The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment of T3, the active form of TH, increases the recruitment of thermogenic capacity in interscapular BAT of male mice through hyperplasia by promoting the TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals the heterogeneous nature and hierarchical trajectory within adipocyte progenitor cells of interscapular BAT. Further analyses suggest that T3 facilitates cell state transition from a more stem-like state towards a more committed adipogenic state and promotes cell cycle progression towards a mitotic state in adipocyte progenitor cells, through mechanisms involving the action of Myc on glycolysis. Our findings elucidate the mechanisms underlying the TH action in adipocyte progenitors residing in BAT and provide a framework for better understanding of the TH effects on hyperplastic growth and adaptive thermogenesis in BAT depot at a single-cell level.

Suggested Citation

  • Shengnan Liu & Siyi Shen & Ying Yan & Chao Sun & Zhiqiang Lu & Hua Feng & Yiruo Ma & Zhili Tang & Jing Yu & Yuting Wu & Balázs Gereben & Petra Mohácsik & Csaba Fekete & Xiaoyun Feng & Feixiang Yuan & , 2022. "Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31154-1
    DOI: 10.1038/s41467-022-31154-1
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    References listed on IDEAS

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    1. Wenfei Sun & Hua Dong & Miroslav Balaz & Michal Slyper & Eugene Drokhlyansky & Georgia Colleluori & Antonio Giordano & Zuzana Kovanicova & Patrik Stefanicka & Lucia Balazova & Lianggong Ding & Anna So, 2020. "snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis," Nature, Nature, vol. 587(7832), pages 98-102, November.
    2. Petra C. Schwalie & Hua Dong & Magda Zachara & Julie Russeil & Daniel Alpern & Nassila Akchiche & Christian Caprara & Wenfei Sun & Kai-Uwe Schlaudraff & Gianni Soldati & Christian Wolfrum & Bart Depla, 2018. "A stromal cell population that inhibits adipogenesis in mammalian fat depots," Nature, Nature, vol. 559(7712), pages 103-108, July.
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    1. Xin Pan & Lan Wang & Juntang Yang & Yingge Li & Min Xu & Chenxi Liang & Lulu Liu & Zhongzheng Li & Cong Xia & Jiaojiao Pang & Mengyuan Wang & Meng Li & Saiya Guo & Peishuo Yan & Chen Ding & Ivan O. Ro, 2024. "TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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