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Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance

Author

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  • Yan-Ting Chen

    (Washington State University)

  • Qi-Yuan Yang

    (Washington State University)

  • Yun Hu

    (Washington State University)

  • Xiang-Dong Liu

    (Washington State University)

  • Jeanene M. Avila

    (Washington State University)

  • Mei-Jun Zhu

    (Washington State University)

  • Peter W. Nathanielsz

    (University of Wyoming
    Texas Biomedical Research Institute)

  • Min Du

    (Washington State University)

Abstract

Maternal obesity (MO) predisposes offspring to obesity and metabolic disorders but little is known about the contribution of offspring brown adipose tissue (BAT). We find that MO impairs fetal BAT development, which persistently suppresses BAT thermogenesis and primes female offspring to metabolic dysfunction. In fetal BAT, MO enhances expression of Dio3, which encodes deiodinase 3 (D3) to catabolize triiodothyronine (T3), while a maternally imprinted long noncoding RNA, Dio3 antisense RNA (Dio3os), is inhibited, leading to intracellular T3 deficiency and suppression of BAT development. Gain and loss of function shows Dio3os reduces D3 content and enhances BAT thermogenesis, rendering female offspring resistant to high fat diet-induced obesity. Attributing to Dio3os inactivation, its promoter has higher DNA methylation in obese dam oocytes which persists in fetal and adult BAT, uncovering an oocyte origin of intergenerational obesity. Overall, our data uncover key features of Dio3os activation in BAT to prevent intergenerational obesity and metabolic dysfunctions.

Suggested Citation

  • Yan-Ting Chen & Qi-Yuan Yang & Yun Hu & Xiang-Dong Liu & Jeanene M. Avila & Mei-Jun Zhu & Peter W. Nathanielsz & Min Du, 2021. "Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27171-1
    DOI: 10.1038/s41467-021-27171-1
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