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Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection

Author

Listed:
  • Yuhao Weng

    (Jiangxi Normal University)

  • Huihong Chen

    (Jiangxi Normal University)

  • Xiaoqian Chen

    (Jiangxi Normal University)

  • Huilin Yang

    (Jiangxi Normal University)

  • Chia-Hung Chen

    (City University of Hong Kong)

  • Hongliang Tan

    (Jiangxi Normal University)

Abstract

The prodrug approach has emerged as a promising solution to combat bacterial resistance and enhance treatment efficacy against bacterial infections. Here, we report an adenosine triphosphate (ATP)-activated prodrug system for on-demand treatment of bacterial infection. The prodrug system benefits from the synergistic action of zeolitic imidazolate framework-8 and polyacrylamide hydrogel microsphere, which simultaneously transports indole-3-acetic acid and horseradish peroxidase in a single carrier while preventing the premature activation of indole-3-acetic acid. The ATP-responsive characteristic of zeolitic imidazolate framework-8 allows the prodrug system to be activated by the ATP secreted by bacteria to generate reactive oxygen species (ROS), displaying exceptional broad-spectrum antimicrobial ability. Upon disruption of the bacterial membrane by ROS, the leaked intracellular ATP from dead bacteria can accelerate the activation of the prodrug system to further enhance antibacterial efficiency. In vivo experiments in a mouse model demonstrates the applicability of the prodrug system for wound disinfection with minimal side effects.

Suggested Citation

  • Yuhao Weng & Huihong Chen & Xiaoqian Chen & Huilin Yang & Chia-Hung Chen & Hongliang Tan, 2022. "Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32453-3
    DOI: 10.1038/s41467-022-32453-3
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    References listed on IDEAS

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    1. Ran Mo & Tianyue Jiang & Rocco DiSanto & Wanyi Tai & Zhen Gu, 2014. "ATP-triggered anticancer drug delivery," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    2. Zhao Zhao & Jinglin Fu & Soma Dhakal & Alexander Johnson-Buck & Minghui Liu & Ting Zhang & Neal W. Woodbury & Yan Liu & Nils G. Walter & Hao Yan, 2016. "Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    3. Mickey Urdea & Laura A. Penny & Stuart S. Olmsted & Maria Y. Giovanni & Peter Kaspar & Andrew Shepherd & Penny Wilson & Carol A. Dahl & Steven Buchsbaum & Gerry Moeller & Deborah C. Hay Burgess, 2006. "Requirements for high impact diagnostics in the developing world," Nature, Nature, vol. 444(1), pages 73-79, November.
    4. Hongliang Tan & Song Guo & Ngoc-Duy Dinh & Rongcong Luo & Lin Jin & Chia-Hung Chen, 2017. "Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
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