IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32453-3.html
   My bibliography  Save this article

Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection

Author

Listed:
  • Yuhao Weng

    (Jiangxi Normal University)

  • Huihong Chen

    (Jiangxi Normal University)

  • Xiaoqian Chen

    (Jiangxi Normal University)

  • Huilin Yang

    (Jiangxi Normal University)

  • Chia-Hung Chen

    (City University of Hong Kong)

  • Hongliang Tan

    (Jiangxi Normal University)

Abstract

The prodrug approach has emerged as a promising solution to combat bacterial resistance and enhance treatment efficacy against bacterial infections. Here, we report an adenosine triphosphate (ATP)-activated prodrug system for on-demand treatment of bacterial infection. The prodrug system benefits from the synergistic action of zeolitic imidazolate framework-8 and polyacrylamide hydrogel microsphere, which simultaneously transports indole-3-acetic acid and horseradish peroxidase in a single carrier while preventing the premature activation of indole-3-acetic acid. The ATP-responsive characteristic of zeolitic imidazolate framework-8 allows the prodrug system to be activated by the ATP secreted by bacteria to generate reactive oxygen species (ROS), displaying exceptional broad-spectrum antimicrobial ability. Upon disruption of the bacterial membrane by ROS, the leaked intracellular ATP from dead bacteria can accelerate the activation of the prodrug system to further enhance antibacterial efficiency. In vivo experiments in a mouse model demonstrates the applicability of the prodrug system for wound disinfection with minimal side effects.

Suggested Citation

  • Yuhao Weng & Huihong Chen & Xiaoqian Chen & Huilin Yang & Chia-Hung Chen & Hongliang Tan, 2022. "Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32453-3
    DOI: 10.1038/s41467-022-32453-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32453-3
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-32453-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ran Mo & Tianyue Jiang & Rocco DiSanto & Wanyi Tai & Zhen Gu, 2014. "ATP-triggered anticancer drug delivery," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    2. Zhao Zhao & Jinglin Fu & Soma Dhakal & Alexander Johnson-Buck & Minghui Liu & Ting Zhang & Neal W. Woodbury & Yan Liu & Nils G. Walter & Hao Yan, 2016. "Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    3. Hongliang Tan & Song Guo & Ngoc-Duy Dinh & Rongcong Luo & Lin Jin & Chia-Hung Chen, 2017. "Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    4. Mickey Urdea & Laura A. Penny & Stuart S. Olmsted & Maria Y. Giovanni & Peter Kaspar & Andrew Shepherd & Penny Wilson & Carol A. Dahl & Steven Buchsbaum & Gerry Moeller & Deborah C. Hay Burgess, 2006. "Requirements for high impact diagnostics in the developing world," Nature, Nature, vol. 444(1), pages 73-79, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Danping Tian & Ruipeng Hao & Xiaoming Zhang & Hu Shi & Yuwei Wang & Linfeng Liang & Haichao Liu & Hengquan Yang, 2023. "Multi-compartmental MOF microreactors derived from Pickering double emulsions for chemo-enzymatic cascade catalysis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Vishal Maingi & Zhao Zhang & Chris Thachuk & Namita Sarraf & Edwin R. Chapman & Paul W. K. Rothemund, 2023. "Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Lee F Schroeder & Ali Elbireer & J Brooks Jackson & Timothy K Amukele, 2015. "Laboratory Diagnostics Market in East Africa: A Survey of Test Types, Test Availability, and Test Prices in Kampala, Uganda," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-14, July.
    4. Huanqing Cui & Yage Zhang & Sihan Liu & Yang Cao & Qingming Ma & Yuan Liu & Haisong Lin & Chang Li & Yang Xiao & Sammer Ul Hassan & Ho Cheung Shum, 2024. "Thermo-responsive aqueous two-phase system for two-level compartmentalization," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Gebremedhin Beedemariam Gebretekle & Damen Haile Mariam & Workeabeba Abebe & Wondwossen Amogne & Admasu Tenna & Teferi Gedif Fenta & Michael Libman & Cedric P Yansouni & Makeda Semret, 2018. "Opportunities and barriers to implementing antibiotic stewardship in low and middle-income countries: Lessons from a mixed-methods study in a tertiary care hospital in Ethiopia," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-15, December.
    6. Feipeng Chen & Xiufeng Li & Yafeng Yu & Qingchuan Li & Haisong Lin & Lizhi Xu & Ho Cheung Shum, 2023. "Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Jing Mu & Chunxiao Li & Yu Shi & Guoyong Liu & Jianhua Zou & Dong-Yang Zhang & Chao Jiang & Xiuli Wang & Liangcan He & Peng Huang & Yuxin Yin & Xiaoyuan Chen, 2022. "Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    8. Alex M. Yoshikawa & Alexandra E. Rangel & Liwei Zheng & Leighton Wan & Linus A. Hein & Amani A. Hariri & Michael Eisenstein & H. Tom Soh, 2023. "A massively parallel screening platform for converting aptamers into molecular switches," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    9. Cecilia Ferreyra & Jennifer Osborn & Francis Moussy & Emilie Alirol & Monica Lahra & David Whiley & William Shafer & Magnus Unemo & Jeffrey Klausner & Cassandra Kelly Cirino & Teodora Wi, 2020. "Developing target product profiles for Neisseria gonorrhoeae diagnostics in the context of antimicrobial resistance: An expert consensus," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-15, September.
    10. Sara Rojas-Vázquez & Beatriz Lozano-Torres & Alba García-Fernández & Irene Galiana & Ana Perez-Villalba & Pablo Martí-Rodrigo & M. José Palop & Marcia Domínguez & Mar Orzáez & Félix Sancenón & Juan F., 2024. "A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32453-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.