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ATP-triggered anticancer drug delivery

Author

Listed:
  • Ran Mo

    (University of North Carolina at Chapel Hill and North Carolina State University
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
    State Key Laboratory of Natural Medicines, China Pharmaceutical University)

  • Tianyue Jiang

    (University of North Carolina at Chapel Hill and North Carolina State University
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
    State Key Laboratory of Natural Medicines, China Pharmaceutical University)

  • Rocco DiSanto

    (University of North Carolina at Chapel Hill and North Carolina State University)

  • Wanyi Tai

    (University of North Carolina at Chapel Hill and North Carolina State University
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill)

  • Zhen Gu

    (University of North Carolina at Chapel Hill and North Carolina State University
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill)

Abstract

Stimuli-triggered drug delivery systems have been increasingly used to promote physiological specificity and on-demand therapeutic efficacy of anticancer drugs. Here we utilize adenosine-5'-triphosphate (ATP) as a trigger for the controlled release of anticancer drugs. We demonstrate that polymeric nanocarriers functionalized with an ATP-binding aptamer-incorporated DNA motif can selectively release the intercalating doxorubicin via a conformational switch when in an ATP-rich environment. The half-maximal inhibitory concentration of ATP-responsive nanovehicles is 0.24 μM in MDA-MB-231 cells, a 3.6-fold increase in the cytotoxicity compared with that of non-ATP-responsive nanovehicles. Equipped with an outer shell crosslinked by hyaluronic acid, a specific tumour-targeting ligand, the ATP-responsive nanocarriers present an improvement in the chemotherapeutic inhibition of tumour growth using xenograft MDA-MB-231 tumour-bearing mice. This ATP-triggered drug release system provides a more sophisticated drug delivery system, which can differentiate ATP levels to facilitate the selective release of drugs.

Suggested Citation

  • Ran Mo & Tianyue Jiang & Rocco DiSanto & Wanyi Tai & Zhen Gu, 2014. "ATP-triggered anticancer drug delivery," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4364
    DOI: 10.1038/ncomms4364
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    Cited by:

    1. Alex M. Yoshikawa & Alexandra E. Rangel & Liwei Zheng & Leighton Wan & Linus A. Hein & Amani A. Hariri & Michael Eisenstein & H. Tom Soh, 2023. "A massively parallel screening platform for converting aptamers into molecular switches," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yuhao Weng & Huihong Chen & Xiaoqian Chen & Huilin Yang & Chia-Hung Chen & Hongliang Tan, 2022. "Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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