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Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions

Author

Listed:
  • Hongliang Tan

    (National University of Singapore)

  • Song Guo

    (National University of Singapore)

  • Ngoc-Duy Dinh

    (National University of Singapore)

  • Rongcong Luo

    (National University of Singapore)

  • Lin Jin

    (National University of Singapore)

  • Chia-Hung Chen

    (National University of Singapore
    Singapore Institute for Neurotechnology (SINAPSE)
    Biomedical Institute for Global Health Research and Technology)

Abstract

In nature, individual cells contain multiple isolated compartments in which cascade enzymatic reactions occur to form essential biological products with high efficiency. Here, we report a cell-inspired design of functional hydrogel particles with multiple compartments, in which different enzymes are spatially immobilized in distinct domains that enable engineered, one-pot, tandem reactions. The dense packing of different compartments in the hydrogel particle enables effective transportation of reactants to ensure that the products are generated with high efficiency. To demonstrate the advantages of micro-environmental modifications, we employ the copolymerization of acrylic acid, which leads to the formation of heterogeneous multi-compartmental hydrogel particles with different pH microenvironments. Upon the positional assembly of glucose oxidase and magnetic nanoparticles, these hydrogel particles are able to process a glucose-triggered, incompatible, multistep tandem reaction in one pot. Furthermore, based on the high cytotoxicity of hydroxyl radicals, a glucose-powered therapeutic strategy to kill cancer cells was approached.

Suggested Citation

  • Hongliang Tan & Song Guo & Ngoc-Duy Dinh & Rongcong Luo & Lin Jin & Chia-Hung Chen, 2017. "Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00757-4
    DOI: 10.1038/s41467-017-00757-4
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    Cited by:

    1. Huanqing Cui & Yage Zhang & Sihan Liu & Yang Cao & Qingming Ma & Yuan Liu & Haisong Lin & Chang Li & Yang Xiao & Sammer Ul Hassan & Ho Cheung Shum, 2024. "Thermo-responsive aqueous two-phase system for two-level compartmentalization," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yuhao Weng & Huihong Chen & Xiaoqian Chen & Huilin Yang & Chia-Hung Chen & Hongliang Tan, 2022. "Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Feipeng Chen & Xiufeng Li & Yafeng Yu & Qingchuan Li & Haisong Lin & Lizhi Xu & Ho Cheung Shum, 2023. "Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Danping Tian & Ruipeng Hao & Xiaoming Zhang & Hu Shi & Yuwei Wang & Linfeng Liang & Haichao Liu & Hengquan Yang, 2023. "Multi-compartmental MOF microreactors derived from Pickering double emulsions for chemo-enzymatic cascade catalysis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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