IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32417-7.html
   My bibliography  Save this article

A mid-infrared lab-on-a-chip for dynamic reaction monitoring

Author

Listed:
  • Borislav Hinkov

    (TU Wien)

  • Florian Pilat

    (TU Wien)

  • Laurin Lux

    (TU Wien)

  • Patricia L. Souza

    (TU Wien
    LabSem-CETUC, Pontifícia Universidade Católica do Rio de Janeiro)

  • Mauro David

    (TU Wien)

  • Andreas Schwaighofer

    (TU Wien)

  • Daniela Ristanić

    (TU Wien)

  • Benedikt Schwarz

    (TU Wien)

  • Hermann Detz

    (TU Wien
    Brno University of Technology)

  • Aaron M. Andrews

    (TU Wien)

  • Bernhard Lendl

    (TU Wien)

  • Gottfried Strasser

    (TU Wien)

Abstract

Mid-infrared spectroscopy is a sensitive and selective technique for probing molecules in the gas or liquid phase. Investigating chemical reactions in bio-medical applications such as drug production is recently gaining particular interest. However, monitoring dynamic processes in liquids is commonly limited to bulky systems and thus requires time-consuming offline analytics. In this work, we show a next-generation, fully-integrated and robust chip-scale sensor for online measurements of molecule dynamics in a liquid solution. Our fingertip-sized device utilizes quantum cascade technology, combining the emitter, sensing section and detector on a single chip. This enables real-time measurements probing only microliter amounts of analyte in an in situ configuration. We demonstrate time-resolved device operation by analyzing temperature-induced conformational changes of the model protein bovine serum albumin in heavy water. Quantitative measurements reveal excellent performance characteristics in terms of sensor linearity, wide coverage of concentrations, extending from 0.075 mg ml−1 to 92 mg ml−1 and a 55-times higher absorbance than state-of-the-art bulky and offline reference systems.

Suggested Citation

  • Borislav Hinkov & Florian Pilat & Laurin Lux & Patricia L. Souza & Mauro David & Andreas Schwaighofer & Daniela Ristanić & Benedikt Schwarz & Hermann Detz & Aaron M. Andrews & Bernhard Lendl & Gottfri, 2022. "A mid-infrared lab-on-a-chip for dynamic reaction monitoring," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32417-7
    DOI: 10.1038/s41467-022-32417-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32417-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32417-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Benedikt Schwarz & Peter Reininger & Daniela Ristanić & Hermann Detz & Aaron Maxwell Andrews & Werner Schrenk & Gottfried Strasser, 2014. "Monolithically integrated mid-infrared lab-on-a-chip using plasmonics and quantum cascade structures," Nature Communications, Nature, vol. 5(1), pages 1-7, September.
    2. Andreas Hugi & Gustavo Villares & Stéphane Blaser & H. C. Liu & Jérôme Faist, 2012. "Mid-infrared frequency comb based on a quantum cascade laser," Nature, Nature, vol. 492(7428), pages 229-233, December.
    3. Gustavo Villares & Andreas Hugi & Stéphane Blaser & Jérôme Faist, 2014. "Dual-comb spectroscopy based on quantum-cascade-laser frequency combs," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    4. Iban Amenabar & Simon Poly & Wiwat Nuansing & Elmar H. Hubrich & Alexander A. Govyadinov & Florian Huth & Roman Krutokhvostov & Lianbing Zhang & Mato Knez & Joachim Heberle & Alexander M. Bittner & Ra, 2013. "Structural analysis and mapping of individual protein complexes by infrared nanospectroscopy," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hamza Dely & Mahdieh Joharifar & Laureline Durupt & Armands Ostrovskis & Richard Schatz & Thomas Bonazzi & Gregory Maisons & Djamal Gacemi & Toms Salgals & Lu Zhang & Sandis Spolitis & Yan-Ting Sun & , 2024. "Unipolar quantum optoelectronics for high speed direct modulation and transmission in 8–14 µm atmospheric window," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Qiang Wang & Zhen Wang & Hui Zhang & Shoulin Jiang & Yingying Wang & Wei Jin & Wei Ren, 2022. "Dual-comb photothermal spectroscopy," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    2. Prati, F. & Lugiato, L.A. & Gatti, A. & Columbo, L. & Silvestri, C. & Gioannini, M. & Brambilla, M. & Piccardo, M. & Capasso, F., 2021. "Global and localised temporal structures in driven ring quantum cascade lasers," Chaos, Solitons & Fractals, Elsevier, vol. 153(P1).
    3. Dingding Ren & Chao Dong & Sadhvikas J. Addamane & David Burghoff, 2022. "High-quality microresonators in the longwave infrared based on native germanium," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    4. Chengying Bao & Zhiquan Yuan & Lue Wu & Myoung-Gyun Suh & Heming Wang & Qiang Lin & Kerry J. Vahala, 2021. "Architecture for microcomb-based GHz-mid-infrared dual-comb spectroscopy," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    5. Carolin P. Bauer & Zofia A. Bejm & Michelle K. Bollier & Justinas Pupeikis & Benjamin Willenberg & Ursula Keller & Christopher R. Phillips, 2024. "High-sensitivity dual-comb and cross-comb spectroscopy across the infrared using a widely tunable and free-running optical parametric oscillator," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Xuezhi Ma & Qiushi Liu & Ning Yu & Da Xu & Sanggon Kim & Zebin Liu & Kaili Jiang & Bryan M. Wong & Ruoxue Yan & Ming Liu, 2021. "6 nm super-resolution optical transmission and scattering spectroscopic imaging of carbon nanotubes using a nanometer-scale white light source," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    7. Arrigo Calzolari & Corey Oses & Cormac Toher & Marco Esters & Xiomara Campilongo & Sergei P. Stepanoff & Douglas E. Wolfe & Stefano Curtarolo, 2022. "Plasmonic high-entropy carbides," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    8. Xingwei Gao & Hao He & Scott Sobolewski & Alexander Cerjan & Chia Wei Hsu, 2024. "Dynamic gain and frequency comb formation in exceptional-point lasers," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    9. Dmitry Kazakov & Theodore P. Letsou & Maximilian Beiser & Yiyang Zhi & Nikola Opačak & Marco Piccardo & Benedikt Schwarz & Federico Capasso, 2024. "Active mid-infrared ring resonators," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    10. Mingchen Liu & Robert M. Gray & Luis Costa & Charles R. Markus & Arkadev Roy & Alireza Marandi, 2023. "Mid-infrared cross-comb spectroscopy," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32417-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.