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ROR2 regulates self-renewal and maintenance of hair follicle stem cells

Author

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  • Anthony Veltri

    (de Duve Institute, Université catholique de Louvain)

  • Christopher M. R. Lang

    (de Duve Institute, Université catholique de Louvain)

  • Gaia Cangiotti

    (de Duve Institute, Université catholique de Louvain)

  • Chim Kei Chan

    (de Duve Institute, Université catholique de Louvain)

  • Wen-Hui Lien

    (de Duve Institute, Université catholique de Louvain)

Abstract

Hair follicles undergo cycles of regeneration fueled by hair follicle stem cells (HFSCs). While β-catenin-dependent canonical Wnt signaling has been extensively studied and implicated in HFSC activation and fate determination, very little is known about the function of β-catenin-independent Wnt signaling in HFSCs. In this study, we investigate the functional role of ROR2, a Wnt receptor, in HFSCs. By analyzing Ror2-depleted HFSCs, we uncover that ROR2 is not only essential to regulate Wnt-activated signaling that is responsible for HFSC activation and self-renewal, but it is also required to maintain proper ATM/ATR-dependent DNA damage response, which is indispensable for the long-term maintenance of HFSCs. In analyzing HFSCs lacking β-catenin, we identify a compensatory role of ROR2-PKC signaling in protecting β-catenin-null HFSCs from the loss of stem cell pool. Collectively, our study unveils a previously unrecognized role of ROR2 in regulation of stem cell self-renewal and maintenance.

Suggested Citation

  • Anthony Veltri & Christopher M. R. Lang & Gaia Cangiotti & Chim Kei Chan & Wen-Hui Lien, 2022. "ROR2 regulates self-renewal and maintenance of hair follicle stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32239-7
    DOI: 10.1038/s41467-022-32239-7
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    References listed on IDEAS

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