IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v447y2007i7142d10.1038_nature05766.html
   My bibliography  Save this article

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Author

Listed:
  • Mayumi Ito

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Zaixin Yang

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Thomas Andl

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Chunhua Cui

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Noori Kim

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Sarah E. Millar

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • George Cotsarelis

    (Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

Abstract

A good hair day? The mammalian hair follicle is thought to form anew only during development, and loss of an adult follicle is generally considered permanent. Fifty years ago in Nature, Billingham and Russel reported 'hair neogenesis' in rabbit skin, but this was later discounted. Now it is back, with the discovery that hair follicle regeneration is triggered by wounding the skin of adult mice. This suggests that mammalian skin responds to wounding with greater plasticity and regenerative capacity than was previously believed, and has implications for those studying wound healing, tissue regeneration and stem cell function.

Suggested Citation

  • Mayumi Ito & Zaixin Yang & Thomas Andl & Chunhua Cui & Noori Kim & Sarah E. Millar & George Cotsarelis, 2007. "Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding," Nature, Nature, vol. 447(7142), pages 316-320, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7142:d:10.1038_nature05766
    DOI: 10.1038/nature05766
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05766
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05766?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marianna Yusupova & Roi Ankawa & Yahav Yosefzon & David Meiri & Ido Bachelet & Yaron Fuchs, 2023. "Apoptotic dysregulation mediates stem cell competition and tissue regeneration," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Anthony Veltri & Christopher M. R. Lang & Gaia Cangiotti & Chim Kei Chan & Wen-Hui Lien, 2022. "ROR2 regulates self-renewal and maintenance of hair follicle stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Yang Yang & Chenyu Chu & Li Liu & Chenbing Wang & Chen Hu & Shengan Rung & Yi Man & Yili Qu, 2023. "Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:447:y:2007:i:7142:d:10.1038_nature05766. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.